Wang Dan, Na Quan, Song Wei-Wei, Song Gui-Yu
Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China.
Am J Perinatol. 2014 Oct;31(9):729-34. doi: 10.1055/s-0033-1361832. Epub 2014 Mar 28.
Previous studies have suggested that the expression and function of placenta-specific microRNAs (miRNAs) are associated with placenta trophoblastic proliferation and invasion. This study investigated whether the altered expression of placenta-specific miRNAs was involved in the development of fetal growth.
Placenta tissues were obtained from pregnant women with large for gestational age (LGA), intrauterine growth retardation (IUGR), and appropriate for gestational age (AGA) infants (n = 30 in each group). Real-time quantitative reverse transcription-polymerase chain reaction was used to analyze the expression of relative placenta-specific miRNAs in human placental tissues from three different groups.
Compared with the LGA and healthy control (AGA) groups; the expression of miR-518b was decreased, whereas miR-519a was significantly increased in the placentas from the IUGR group (p < 0.05).
This study suggests that altered expression of placenta-specific miRNAs (miR-518b and miR-519a) may be involved in the development of IUGR.
先前的研究表明，胎盘特异性微小RNA（miRNA）的表达和功能与胎盘滋养层细胞的增殖和侵袭有关。本研究调查了胎盘特异性miRNA表达的改变是否参与胎儿生长发育。
从患有大于胎龄儿（LGA）、宫内生长受限（IUGR）和适于胎龄儿（AGA）的孕妇中获取胎盘组织（每组n = 30）。采用实时定量逆转录-聚合酶链反应分析来自三个不同组的人胎盘组织中相对胎盘特异性miRNA的表达。
与LGA组和健康对照组（AGA）相比，IUGR组胎盘组织中miR-518b的表达降低，而miR-519a的表达显著增加（p < 0.05）。
本研究表明，胎盘特异性miRNA（miR-518b和miR-519a）表达的改变可能参与IUGR的发生发展。
