Kurtaran Hanifi, Ark Nebil, Serife Ugur K, Sert Huseyin, Ozboduroglu Akin Altug, Kosar Ali, Gunduz Mehmet
Department of Otorhinolaryngology Head and Neck Surgery, Fatih University Faculty of Medicine, Ankara, Turkey.
Department of Anesthesiology, Fatih University Faculty of Medicine, Ankara, Turkey.
Curr Ther Res Clin Exp. 2010 Apr;71(2):105-10. doi: 10.1016/j.curtheres.2010.03.003.
Ankaferd BloodStopper (ABS) is a standardized herbal compound consisting of 5 different plant extracts. ABS, as a topical medicinal product, has been approved by the Turkish Ministry of Health for the management of dermal, external postsurgical and postdental surgery bleedings.
The aim of this study was to assess the hemostatic effect of ABS in an experimental epistaxis model.
Adult female New Zealand rabbits were used in this study. Standardized full-thickness mucosal wounds were created to provide bleeding on the right and left side of the nasal septum of rabbits with a 3-mm surgical punch. To stop bleeding, the wounds were treated with topical ABS on one side and with topical isotonic saline solution as a control on the other side of the nasal septum. Investigators were blinded to treatment. The duration of bleeding was measured in order to compare the hemo-static effect with ABS or topical isotonic saline solution. The wounds were observed for the duration of bleeding in order to compare the hemostatic effect of ABS with isotonic saline solution and acute adverse effects (AEs) for 30 minutes by a researcher blinded to treatment groups.
Six rabbits (mean weight, 2.6 kg [range, 2.3-3.1 kg]) were used in this study. Mean (SD) bleeding time in the wounds administered ABS (98 [17] sec) was significantly less than that of the controls (266 [36] sec; P = 0.004). No AEs were observed up to 30 minutes after study initiation.
This study suggests that ABS may be more effective in reducing time to hemostasis when compared with isotonic saline solution in this epistaxis model in rabbits.
安卡非德止血剂（ABS）是一种由5种不同植物提取物组成的标准化草药化合物。作为一种局部用药品，ABS已获得土耳其卫生部批准，用于治疗皮肤、外科术后及牙科术后的外部出血。
本研究旨在评估ABS在实验性鼻出血模型中的止血效果。
本研究使用成年雌性新西兰兔。用3毫米手术打孔器在兔鼻中隔的左右两侧制造标准化的全层黏膜伤口以引起出血。为了止血，一侧伤口用局部ABS治疗，另一侧鼻中隔伤口用局部等渗盐溶液作为对照。研究人员对治疗情况不知情。测量出血持续时间，以比较ABS或局部等渗盐溶液的止血效果。由对治疗组不知情的研究人员观察伤口的出血持续时间，以比较ABS与等渗盐溶液的止血效果及30分钟内的急性不良反应（AE）。
本研究使用了6只兔（平均体重2.6千克[范围2.3 - 3.1千克]）。使用ABS处理的伤口的平均（标准差）出血时间（98 [17]秒）显著短于对照组（266 [36]秒；P = 0.004）。在研究开始后30分钟内未观察到不良反应。
本研究表明，在该兔鼻出血模型中，与等渗盐溶液相比，ABS在减少止血时间方面可能更有效。
