Schned Alan R, Lenz Petra, Moore Lee E, Johnson Alison, Jones Michael, Kida Masatoshi, Silverman Debra T, Schwenn Molly, Kelsey Karl T, Andrew Angeline S, Baris Dalsu, Karagas Margaret R
Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire USA.
Division of Cancer Epidemiology and Genetics, Science Applications International Corporation-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD 21702.
ISRN Pathol. 2012;2012. doi: 10.5402/2012/283670.
We investigate the distribution of bladder tumor category and stage in Northern New England by geographic region, smoking status and over time. 1091 incident bladder cancer cases from the New England Bladder Cancer Study (NEBCS), a large population-based case-control study carried out in Maine, New Hampshire and Vermont (2001-2004), and 680 bladder cancer cases from previous case-control studies in New Hampshire (1994-2000) were used in the analysis. Of 1091 incident bladder cancer cases from the NEBCS, 26.7% of tumors were papillary urothelial neoplasms of low malignant potential (PUNLMP), 26.8% low-grade papillary urothelial carcinomas (PUC-LG), 31.3% high-grade papillary urothelial carcinomas (PUC-HG), 9.1% non-papillary urothelial carcinomas (non-PUC), and 4.3% carcinoma in situ (CIS). Approximately 70% of cases were non-invasive (Tis/Ta), and all PUNLMP cases were of the Ta category. By contrast, half of all PUC-HG carcinomas were invasive. Short-term time trend analysis within the NEBCS (2001-2004) indicated an increase in the percentage of PUNLMP (p-trend<0.0001) paralleled by a decrease in PUC-LG (p-trend=0.02), and for PUC-LG an increase in the percentage of non-invasive tumors (p-trend 0.04). Our findings suggest possible short-term trends with an increase in the percentage of PUNLMP and a change in the percentage of PUC-LG towards non-invasive disease.
我们按地理区域、吸烟状况以及随时间推移，对新英格兰北部膀胱肿瘤的类别和分期分布情况展开研究。分析采用了新英格兰膀胱癌研究（NEBCS）中的1091例原发性膀胱癌病例，该研究是在缅因州、新罕布什尔州和佛蒙特州开展的一项大型基于人群的病例对照研究（2001 - 2004年），以及新罕布什尔州此前病例对照研究（1994 - 2000年）中的680例膀胱癌病例。在NEBCS的1091例原发性膀胱癌病例中，26.7%的肿瘤为低恶性潜能乳头状尿路上皮肿瘤（PUNLMP），26.8%为低级别乳头状尿路上皮癌（PUC - LG），31.3%为高级别乳头状尿路上皮癌（PUC - HG），9.1%为非乳头状尿路上皮癌（非PUC），4.3%为原位癌（CIS）。约70%的病例为非侵袭性（Tis/Ta），所有PUNLMP病例均为Ta类别。相比之下，所有PUC - HG癌中有一半为侵袭性。NEBCS（2001 - 2004年）内的短期时间趋势分析表明，PUNLMP的百分比有所增加（p趋势<0.0001），同时PUC - LG的百分比有所下降（p趋势 = 0.02），并且对于PUC - LG，非侵袭性肿瘤的百分比有所增加（p趋势 = 0.04）。我们的研究结果表明可能存在短期趋势，即PUNLMP的百分比增加，以及PUC - LG向非侵袭性疾病的百分比变化。
