Moffat D A, Parker R A, Hardy D G, Macfarlane R
Neuro-otology and Skull Base Surgery Department, Addenbrookes Hospital,Cambridge University Teaching Hospitals NHS Trust,UK.
Centre for Applied Medical Statistics,University of Cambridge,UK.
J Laryngol Otol. 2014 May;128(5):406-15. doi: 10.1017/S0022215114000541. Epub 2014 Mar 31.
To determine factors affecting facial nerve outcome of vestibular schwannoma surgery.
This retrospective cohort study comprised 652 patients. The outcome measure was House-Brackmann classification at two years post-operatively. Univariate and multivariate analyses were carried out to determine the factors affecting facial nerve outcome. The incidence rates of hemifacial spasm, metallic taste and crocodile tear syndrome were recorded.
For tumours less than 1.5 cm, 95 per cent of outcomes were normal, 100 per cent were satisfactory (House-Brackmann grades I-III) and 0 per cent were unsatisfactory (grades IV-VI). For tumours 1.5-2.4 cm, 83 per cent of outcomes were normal, 99 per cent were satisfactory and 1 per cent were unsatisfactory. For tumours 2.5-3.4 cm, 68 per cent of outcomes were normal, 96 per cent were satisfactory and 4 per cent were unsatisfactory. For tumours 3.5-4.4 cm, 52 per cent of outcomes were normal, 80 per cent were satisfactory and 20 per cent were unsatisfactory. For tumours larger than 4.4 cm, 50 per cent of outcomes were normal, 72 per cent were satisfactory and 28 per cent were unsatisfactory.
Tumour size and operation year were significant predictors of facial nerve outcome. The surgical learning curve was steepest for the first 50 patients.
确定影响前庭神经鞘瘤手术面神经预后的因素。
这项回顾性队列研究纳入了652例患者。结局指标为术后两年的House-Brackmann分级。进行单因素和多因素分析以确定影响面神经预后的因素。记录半面痉挛、金属味觉和鳄鱼泪综合征的发生率。
对于小于1.5 cm的肿瘤,95%的预后正常,100%满意(House-Brackmann分级I-III级),0%不满意(IV-VI级)。对于1.5-2.4 cm的肿瘤,83%的预后正常,99%满意,1%不满意。对于2.5-3.4 cm的肿瘤,68%的预后正常,96%满意,4%不满意。对于3.5-4.4 cm的肿瘤,52%的预后正常,80%满意,20%不满意。对于大于4.4 cm的肿瘤,50%的预后正常,72%满意,28%不满意。
肿瘤大小和手术年份是面神经预后的重要预测因素。前50例患者的手术学习曲线最陡。