Department of Neuro-oncology, Hhaider5 Research Group, Rawalpindi, Pakistan.
Rawalpindi Medical University, Rawalpindi, Punjab, Pakistan.
Neurosurg Rev. 2024 Sep 4;47(1):536. doi: 10.1007/s10143-024-02788-0.
To determine the collated rate of postoperative dysgeusia after microsurgical intervention in acoustic neuroma patients.
The systematic review with meta-analysis was undertaken following PRISMA guidelines. A thorough search of PubMed/Medline, the Cochrane Database of Systematic Reviews, and Epistemonikos was undertaken for studies published up until May 16, 2024 reporting postoperative taste disturbance rates after microsurgical intervention for acoustic neuroma. The methodological quality of the included studies was assessed via the Methodological Index for Non-Randomized research (MINORS) tool. Using MedCalc (v. 20.215) software, the random-effects model was developed for proportional meta-analysis.
Eight studies, encompassing 2,402 patients (mean age = 49.06 years; 48.54% female population), were included in the analysis. The overall pooled rate of postoperative dysgeusia following microsurgical management of acoustic neuroma was 23.7% (95% CI: 9.266-42.359, p < 0.0001). When stratified by surgical approach, the rate of postoperative dysgeusia for the retrosigmoid approach was 18.8% (95% CI: 2.821-44.461, p < 0.0001). Postoperative dysgeusia data stratified for other major microsurgical approaches (subtemporal and translabirynthine approaches) was not reported by any of the included studies.
Our systematic review and meta-analysis calculated a collated rate of almost 25% and recognized postoperative dysgeusia as a common complication following microsurgical management of acoustic neuromas. These results highlight the significance of preoperative counselling and the development of strategies that minimize the likelihood of harm to the chorda tympani nerve during microsurgical intervention for acoustic neuroma.
确定听神经瘤患者显微手术后味觉障碍的综合发生率。
按照 PRISMA 指南进行系统综述和荟萃分析。对截至 2024 年 5 月 16 日发表的报告听神经瘤显微手术后味觉障碍发生率的研究进行了全面的 PubMed/Medline、Cochrane 系统评价数据库和 Epistemonikos 检索。使用 Methodological Index for Non-Randomized research (MINORS) 工具评估纳入研究的方法学质量。使用 MedCalc（v. 20.215）软件，开发了随机效应模型进行比例荟萃分析。
纳入了 8 项研究，共 2402 例患者（平均年龄为 49.06 岁；48.54%为女性）。总体上，听神经瘤显微手术后味觉障碍的综合发生率为 23.7%（95% CI：9.266-42.359，p<0.0001）。按手术入路分层，乙状窦后入路术后味觉障碍发生率为 18.8%（95% CI：2.821-44.461，p<0.0001）。纳入的研究均未报告其他主要显微手术入路（经颞下入路和经迷路入路）的术后味觉障碍数据。
我们的系统综述和荟萃分析计算出综合发生率接近 25%，并认识到术后味觉障碍是听神经瘤显微手术后的常见并发症。这些结果强调了术前咨询的重要性，以及制定策略的必要性，以最大限度地减少听神经瘤显微手术中对鼓索神经的损伤。
