Anirudhan T S, Parvathy J
Department of Chemistry, School of Physical and Mathematical Sciences, University of Kerala, Kariavattom, Trivandrum 695 581, India.
Department of Chemistry, School of Physical and Mathematical Sciences, University of Kerala, Kariavattom, Trivandrum 695 581, India.
Int J Biol Macromol. 2014 Jun;67:238-45. doi: 10.1016/j.ijbiomac.2014.03.041. Epub 2014 Mar 28.
A novel semi-interpenetrating polymer network (IPN) based on crosslinked carboxymethyl starch (CL-CMS) and montmorillonite (MMT) was prepared, where carboxymethylation occurs as a result of the reaction between native starch and monochloroacetic acid in isopropanol/water medium at 60°C. The carboxymethyl starch is further crosslinked and made into a semi-IPN with MMT for the release of theophylline. The drug carrier was characterized using FTIR, XRD and surface analysis using SEM. Studies including physio-chemical analysis, swelling behavior, encapsulation efficiency, effect of MMT content, effect of ionic strength and in vitro drug release were carried out. Theophylline encapsulation of up to 74% was achieved and drug release was monitored in SGF (pH 1.2) and SIF (pH 7.4). Results show that the matrix releases drug at a much faster rate in the basic medium than in the acidic medium, thereby holding the promise of developing the semi-IPN system as a potential candidate for the release of theophylline.
制备了一种基于交联羧甲基淀粉（CL-CMS）和蒙脱石（MMT）的新型半互穿聚合物网络（IPN），其中羧甲基化是天然淀粉与一氯乙酸在60°C的异丙醇/水介质中反应的结果。羧甲基淀粉进一步交联并与MMT制成半IPN用于茶碱的释放。使用傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）以及扫描电子显微镜（SEM）进行表面分析对药物载体进行了表征。开展了包括物理化学分析、溶胀行为、包封效率、MMT含量的影响、离子强度的影响以及体外药物释放等研究。实现了高达74%的茶碱包封率，并在模拟胃液（SGF，pH 1.2）和模拟肠液（SIF，pH 7.4）中监测药物释放。结果表明，该基质在碱性介质中释放药物的速度比在酸性介质中快得多，因此有望将该半IPN系统开发成为茶碱释放的潜在候选物。
