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关于DC属植物的民族植物学、植物化学和药理学的综述。

A review on ethnobotany, phytochemistry, and pharmacology of the genus DC.

作者信息

Shu Liangyin, Li Kailin, Yang Suyu, Hu Mengdie, Ming Xinrong, Yan Bingyuan, Guan Liangjun, Xiao Shunli

机构信息

School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, China.

School of Pharmacy, Shandong Second Medical University, Weifang, China.

出版信息

Front Pharmacol. 2024 Nov 15;15:1479963. doi: 10.3389/fphar.2024.1479963. eCollection 2024.

DOI:10.3389/fphar.2024.1479963
PMID:39619617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11604426/
Abstract

The botanical drugs of genus DC. have been traditionally utilized in folk medicine for the treatment of a wide array of illnesses, encompassing fractures, bone wounds, carbuncles and poisoning, bronchitis, bruises, giddy with hypertension of qi, and lung deficiency cough. The genus DC. comprises 15 species widespread in Central, East, and Southeast Asia and 7 species (2 endemic) in China. The review aims to provide a systematic overview of ethnopharmacology, phytochemistry, and pharmacology of DC. and to explore the future therapeutic potential and scientific potential of this genus. The data were systematically collected from books and scientific databases such as PubMed, Web of Science, Google Scholar, CNKI, and doctoral and master's theses. To date, a total of 352 metabolites have been isolated from this genus, and terpenoids, flavonoids, phenylpropanoids, and inositol angelates are the primary contributors to the pharmacological activities of DC. The crude extracts and isolated phytochemical metabolites from this genus have been shown to exhibit various pharmacological activities, including anti-inflammatory, antimicrobial, anti-osteoporotic, anticancer, and antioxidant activities. Despite notable advancements in our understanding of the chemical constituents and pharmacological properties of DC., it is absolutely crucial to conduct additional research into the pharmacology and toxicology of these species to definitively ascertain their safety, efficacy, and quality.

摘要

DC.属的植物药传统上被用于民间医学，治疗多种疾病，包括骨折、骨伤、痈肿和中毒、支气管炎、瘀伤、气逆高血压引起的头晕以及肺虚咳嗽。DC.属包括15个物种，广泛分布于中亚、东亚和东南亚，在中国有7个物种（2个为特有种）。本综述旨在对DC.属的民族药理学、植物化学和药理学进行系统概述，并探索该属未来的治疗潜力和科学潜力。数据是从书籍和科学数据库如PubMed、Web of Science、谷歌学术、中国知网以及博士和硕士论文中系统收集的。迄今为止，已从该属中分离出总共352种代谢产物，萜类化合物、黄酮类化合物、苯丙素类化合物和肌醇当归酸酯是DC.属药理活性的主要贡献者。该属的粗提物和分离出的植物化学代谢产物已显示出具有多种药理活性，包括抗炎、抗菌、抗骨质疏松、抗癌和抗氧化活性。尽管我们对DC.属的化学成分和药理特性的理解有了显著进展，但对这些物种的药理学和毒理学进行更多研究以明确确定其安全性、有效性和质量绝对至关重要。

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