Brouwers J R, Tygat G N
J Pharm Pharmacol. 1978 Mar;30(3):148-51. doi: 10.1111/j.2042-7158.1978.tb13186.x.
Three types of liquid and tablet antacids have been studied in vitro and in vivo: aluminium hydroxide, aluminium hydroxide-magnesium carbonate and hydrotalcite. The effects on gastric pH of antacid suspensions and antacid chewing tablets having identical active ingredients have been studied in 36 volunteers, the sequence of both forms of administration being randomized. Gastric acid secretion was continuously stimulated during the experiment by a pentagastrin infusion. Antacid chewing tablets gave inferior results when compared with the same antacid in liquid. Antacid suspensions are therefore preferred in the treatment of acid-peptic disease.
氢氧化铝、氢氧化铝 - 碳酸镁和水滑石。在36名志愿者中研究了具有相同活性成分的抗酸剂混悬液和抗酸咀嚼片对胃pH值的影响，两种给药形式的顺序均为随机。实验期间通过静脉输注五肽胃泌素持续刺激胃酸分泌。与相同抗酸剂的液体剂型相比，抗酸咀嚼片的效果较差。因此，抗酸剂混悬液更适合用于治疗酸相关性疾病。
