Schmutzler W, Neukirch B, Ziesche R
Institut für Pharmakologie, Medizinische Fakultät, Rheinisch-Westfälische Technische Hochschule Aachen, FRG.
Int Arch Allergy Appl Immunol. 1989;88(1-2):244-6. doi: 10.1159/000234798.
Inosine pranobex (INPX) at concentrations greater than 10(-3) M inhibits significantly the concanavalin A or antihuman IgE induced histamine release from human mast cells. The inosine moiety of the compound does not contribute to this effect, but rather interferes with it. The other component, the salt of dimethylaminopropanol and acetamidobenzoic acid, produces a small but significant inhibition of the histamine release already at 10(-6) M. This effect is due to the acetamidobenzoic acid although the base (dimethylaminopropanol) adds to it. With increasing incubation time, the salt of dimethylaminopropanol and acetamidobenzoic acid looses its histamine release inhibiting effect.
浓度大于10⁻³ M的肌苷普拉诺贝（INPX）可显著抑制伴刀豆球蛋白A或抗人IgE诱导的人肥大细胞组胺释放。该化合物的肌苷部分对此效应无贡献，反而会干扰它。另一种成分，二甲基氨基丙醇与乙酰氨基苯甲酸的盐，在10⁻⁶ M时就能产生微小但显著的组胺释放抑制作用。这种效应归因于乙酰氨基苯甲酸，尽管碱（二甲基氨基丙醇）也有一定作用。随着孵育时间增加，二甲基氨基丙醇与乙酰氨基苯甲酸的盐会失去其组胺释放抑制作用。
