Ziesche R, Eichelberg D, Schmutzler W
Agents Actions. 1987 Apr;20(3-4):172-3. doi: 10.1007/BF02074660.
The effects of Inosine pranobex and its parent compounds inosine and dimethylamino-2-propanol-p-acetamidobenzoic acid (DipPacBa) on the Concanavalin A (ConA)-induced histamine release from human adenoidal mast cells were investigated. Inosine pranobex inhibited the ConA-induced histamine release at concentrations greater than 10(-3) M. Inosine itself (10(-5)-10(-2) M) enhanced the ConA-induced histamine release whereas DipPacBa inhibited the release significantly at concentrations between 10(-6) and 10(-2) M. These results are consistent with the assumption that the effect of Inosine pranobex is due to the DipPacBa moiety.
研究了异丙肌苷及其母体化合物肌苷和二甲基氨基-2-丙醇对乙酰氨基苯甲酸（DipPacBa）对刀豆球蛋白A（ConA）诱导的人腺样体肥大细胞组胺释放的影响。异丙肌苷在浓度大于10（-3）M时抑制ConA诱导的组胺释放。肌苷本身（10（-5）-10（-2）M）增强ConA诱导的组胺释放，而DipPacBa在10（-6）至10（-2）M的浓度下显著抑制释放。这些结果与异丙肌苷的作用归因于DipPacBa部分的假设一致。
