Sridharan Aadhavi, Bendlin Barbara B, Gallagher Catherine L, Oh Jennifer M, Willette Auriel A, Alexander Andrew L, Kemnitz Joseph W, Colman Ricki J, Weindruch Richard H, Johnson Sterling C
Neuroscience Training Program, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA; Medical Scientist Training Program, University of Wisconsin-Madison, 750 Highland Avenue, Madison, WI 53705, USA.
Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; Department of Medicine, University of Wisconsin-Madison, 2500 Overlook Terrace, Madison, WI 53705, USA.
Neurosci Lett. 2014 May 21;569:38-42. doi: 10.1016/j.neulet.2014.03.047. Epub 2014 Mar 29.
The rhesus macaque exhibits age-related brain changes similar to humans, making an excellent model of normal aging. Calorie restriction is a dietary intervention that reduces age-related comorbidities in short-lived animals, and its effects are still under study in rhesus macaques. Here, using deterministic fiber tracking method, we examined the effects of age and calorie restriction on a diffusion tensor imaging measure of white matter integrity, fractional anisotropy (FA), within white matter tracks traversing the anterior (genu) and posterior (splenium) corpus callosum in rhesus monkeys. Our results show: (1) a significant inverse relationship between age and mean FA of tracks traversing the genu and splenium; (2) higher mean FA of the splenium tracks as compared to that of genu tracks across groups; and (3) no significant diet effect on mean track FA through either location. These results are congruent with the age-related decline in white matter integrity reported in humans and monkeys, and the anterior-to-posterior gradient in white matter vulnerability to normal aging in humans. Further studies are warranted to critically evaluate the effect of calorie restriction on brain aging in this unique cohort of elderly primates.
恒河猴表现出与人类相似的与年龄相关的大脑变化，是正常衰老的优秀模型。热量限制是一种饮食干预措施，可减少短命动物中与年龄相关的合并症，其在恒河猴中的作用仍在研究中。在此，我们使用确定性纤维追踪方法，研究了年龄和热量限制对恒河猴中穿过胼胝体前部（膝部）和后部（压部）的白质束中白质完整性的扩散张量成像指标——分数各向异性（FA）的影响。我们的结果表明：（1）穿过膝部和压部的束的年龄与平均FA之间存在显著的负相关关系；（2）与膝部束相比，各年龄组中压部束的平均FA更高；（3）饮食对穿过这两个部位的束的平均FA没有显著影响。这些结果与人类和猴子中报道的与年龄相关的白质完整性下降以及人类白质对正常衰老的易损性从前到后的梯度一致。有必要进行进一步研究，以严格评估热量限制对这一独特老年灵长类动物群体大脑衰老的影响。
