Stricker Nikki H, Salat David H, Kuhn Taylor P, Foley Jessica M, Price Jenessa S, Westlye Lars T, Esterman Michael S, McGlinchey Regina E, Milberg William P, Leritz Elizabeth C
Psychology Service, VA Boston Healthcare System, Boston, MA, USA Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA
Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA Department of Radiology, Harvard Medical School, Boston, MA, USA Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
Am J Alzheimers Dis Other Demen. 2016 Feb;31(1):68-75. doi: 10.1177/1533317515578257. Epub 2015 Apr 22.
Degenerative brain changes in Alzheimer's disease may occur in reverse order of normal brain development based on the retrogenesis model. This study tested whether evidence of reverse myelination was observed in mild cognitive impairment (MCI) using a data-driven analytic approach based on life span developmental data. Whole-brain high-resolution diffusion tensor imaging scans were obtained for 31 patients with MCI and 79 demographically matched healthy older adults. Comparisons across corpus callosum (CC) regions of interest (ROIs) showed decreased fractional anisotropy (FA) in the body but not in the genu or splenium; early-, middle-, and late-myelinating ROIs restricted to the CC revealed decreased FA in late- but not early- or middle-myelinating ROIs. Voxelwise group differences revealed areas of lower FA in MCI, but whole-brain differences were equally distributed across early-, middle-, and late-myelinating regions. Overall, results within the CC support the retrogenesis model, although caution is needed when generalizing these results beyond the CC.
根据逆向发生模型，阿尔茨海默病中大脑的退行性变化可能以与正常大脑发育相反的顺序发生。本研究使用基于寿命发育数据的数据驱动分析方法，测试了在轻度认知障碍（MCI）中是否观察到逆向髓鞘形成的证据。对31例MCI患者和79名人口统计学匹配的健康老年人进行了全脑高分辨率扩散张量成像扫描。跨胼胝体（CC）感兴趣区域（ROI）的比较显示，胼胝体体部的各向异性分数（FA）降低，但膝部或压部未降低；仅限于CC的早期、中期和晚期髓鞘形成ROI显示，晚期髓鞘形成ROI的FA降低，而早期或中期髓鞘形成ROI未降低。体素组差异显示MCI中FA较低的区域，但全脑差异在早期、中期和晚期髓鞘形成区域均匀分布。总体而言，CC内的结果支持逆向发生模型，尽管在将这些结果推广到CC以外时需要谨慎。
