Vogel P, Liu J, Platt K A, Read R W, Thiel M, Vance R B, Brommage R
Department of Pathology, Lexicon Pharmaceuticals Inc, The Woodlands, TX, USA
Department of Metabolism, Lexicon Pharmaceuticals Inc, The Woodlands, TX, USA.
Vet Pathol. 2015 Jan;52(1):224-9. doi: 10.1177/0300985814528218. Epub 2014 Mar 31.
GREMLIN 2 (GREM2)--formerly, protein related to Dan and cerberus (PRDC)-is a potent antagonist of the bone morphogenetic proteins 2 and 4, but little else in known about its functions. We found that Grem2(-/-) mice developed small deformed mandibular and maxillary incisors, indicating that GREMLIN2 is required for normal tooth morphogenesis. Although DEXA scans suggested that bone mineral density might be increased in Grem2(-/-) mice, histology did not reveal any evident bone phenotype. Grem2(-/-) mice did not display any other notable phenotypes evaluated in a high-throughput screening process that encompassed a range of immunologic, metabolic, ophthalmic, and behavioral parameters. Our findings indicate that Grem2 can be added to the growing list of genes that affect tooth development in mice.
GREMLIN 2（GREM2）——以前称为与Dan和Cerberus相关的蛋白质（PRDC）——是骨形态发生蛋白2和4的强效拮抗剂，但对其功能了解甚少。我们发现Grem2基因敲除小鼠发育出小的畸形下颌和上颌切牙，这表明GREMLIN2是正常牙齿形态发生所必需的。尽管双能X线吸收法扫描表明Grem2基因敲除小鼠的骨矿物质密度可能增加，但组织学检查未发现任何明显的骨表型。在涵盖一系列免疫、代谢、眼科和行为参数的高通量筛选过程中，Grem2基因敲除小鼠未表现出任何其他显著的表型。我们的研究结果表明，Grem2可以添加到影响小鼠牙齿发育的不断增加的基因列表中。
