Patton Bethany K, Madadi Surabhi, Pangas Stephanie A
Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Graduate Program in Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030.
Curr Opin Endocr Metab Res. 2021 Jun;18:102-110. doi: 10.1016/j.coemr.2021.03.001. Epub 2021 Mar 11.
The reproductive lifespan of female mammals is limited and ultimately depends on the production of a sufficient number of high quality oocytes from a pool of non-growing primordial follicles that are set aside during embryonic and perinatal development. Recent studies show multiple signaling pathways are responsible for maintaining primordial follicle arrest and regulation of activation. Identification of these pathways and their regulatory mechanisms is essential for developing novel treatments for female infertility, improving existing fertilization techniques, and more recently, restoring the function of cryopreserved ovarian tissue. This review focuses on recent developments in transforming growth factor beta (TGFβ) family signaling in ovarian follicle development and its potential application to therapeutic design. Mouse models have been an essential tool for discovering genes critical for fertility, and recent advancements in human organ culture have additionally allowed for the translation of murine discoveries into human research and clinical settings.
雌性哺乳动物的生殖寿命是有限的，最终取决于从胚胎期和围产期发育期间储备的大量未生长的原始卵泡中产生足够数量的高质量卵母细胞。最近的研究表明，多种信号通路负责维持原始卵泡的静止状态和激活调节。识别这些通路及其调节机制对于开发女性不孕症的新疗法、改进现有受精技术以及最近恢复冷冻保存的卵巢组织的功能至关重要。本综述重点关注转化生长因子β（TGFβ）家族信号在卵巢卵泡发育中的最新进展及其在治疗设计中的潜在应用。小鼠模型一直是发现生育关键基因的重要工具，而人类器官培养的最新进展也使得将小鼠研究成果转化为人类研究和临床应用成为可能。
