McKinnon Andrew, Terpening Zoe, Hickie Ian B, Batchelor Jennifer, Grunstein Ron, Lewis Simon J G, Naismith Sharon L
Healthy Brain Ageing Clinic, The University of Sydney, Camperdown, NSW, Australia Department of Psychology, Macquarie University, North Ryde, NSW, Australia.
Healthy Brain Ageing Clinic, The University of Sydney, Camperdown, NSW, Australia.
J Geriatr Psychiatry Neurol. 2014 Sep;27(3):204-11. doi: 10.1177/0891988714527516. Epub 2014 Mar 31.
To investigate the prevalence of and contributors to poor sleep quality in patients with mild cognitive impairment (MCI).
Data were collected for 158 patients meeting the criteria for MCI. Measures included the Pittsburgh Sleep Quality Index, Geriatric Depression Scale, and Mini-Mental State Examination. Demographic, lifestyle, medication, and substance use data were also collected.
A total of 63% of patients with MCI demonstrated sleep disturbance, a significantly higher rate than that of the controls (44%; chi-square = 8.77; P = .003). Depressive symptoms, cognition, antidepressant usage, alcohol consumption, age, and education were identified as significant predictors of self-reported sleep quality in patients with MCI (R(2) = .327, F 6,145 = 11.729, P < .0001).
Sleep disturbance occurs in around two-thirds of patients with MCI. Interventions addressing depression, cognition, and substance and medication use may improve sleep quality in MCI.
调查轻度认知障碍（MCI）患者睡眠质量差的患病率及其影响因素。
收集了158例符合MCI标准患者的数据。测量指标包括匹兹堡睡眠质量指数、老年抑郁量表和简易精神状态检查表。还收集了人口统计学、生活方式、用药及物质使用数据。
共有63%的MCI患者存在睡眠障碍，这一比例显著高于对照组（44%；卡方=8.77；P = 0.003）。抑郁症状、认知、抗抑郁药使用、饮酒、年龄和教育程度被确定为MCI患者自我报告睡眠质量的重要预测因素（R(2)=0.327，F 6,145 = 11.729，P < 0.0001）。
约三分之二的MCI患者存在睡眠障碍。针对抑郁、认知以及物质和药物使用的干预措施可能会改善MCI患者的睡眠质量。
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