卡氏肺孢子虫肺炎艾滋病患者体内卡氏肺孢子虫特异性免疫复合物的动态变化
Dynamics of Pneumocystis carinii-specific immune complexes in AIDS patients with P. carinii pneumonia.
作者信息
Pifer L L
机构信息
Department of Pediatrics, University of Tennessee, Memphis.
出版信息
J Protozool. 1989 Jan-Feb;36(1):44S-46S. doi: 10.1111/j.1550-7408.1989.tb02690.x.
Pneumocystis carinii-specific immune complexes were detected by immunoblot and enzyme-linked immunosorbent assay (ELISA) in 53% of sera from Acquired Immunodeficiency Syndrome (AIDS) patients with P. carinii pneumonia (PCP). Resolution of glycoprotein antigenemia (50-55 kd = dominant species) appears to correlate with successful PCP drug therapy and recovery. An epitope map has been constructed from immunoblots of P. carinii hydrolysates and from human and murine serum containing P. carinii antigens.
通过免疫印迹法和酶联免疫吸附测定（ELISA）在53%患有卡氏肺孢子虫肺炎（PCP）的获得性免疫缺陷综合征（AIDS）患者血清中检测到卡氏肺孢子虫特异性免疫复合物。糖蛋白抗原血症（50 - 55kd = 主要种类）的消退似乎与PCP药物治疗的成功及康复相关。已根据卡氏肺孢子虫水解产物的免疫印迹以及含有卡氏肺孢子虫抗原的人血清和鼠血清构建了一个表位图谱。
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