对获得性免疫缺陷综合征患者进行卡氏肺孢子虫抗体和抗原血症血清学检测的评估。
Evaluation of serologic tests for Pneumocystis carinii antibody and antigenemia in patients with acquired immunodeficiency syndrome.
作者信息
Maddison S E, Walls K W, Haverkos H W, Juranek D D
出版信息
Diagn Microbiol Infect Dis. 1984 Jan;2(1):69-73. doi: 10.1016/0732-8893(84)90025-7.
Sera from 68 patients with acquired immunodeficiency syndrome and 135 controls were used to evaluate the indirect immunofluorescence and enzyme-linked immunosorbent assays for detection of antibodies to Pneumocystis carinii and a counterimmunoelectrophoresis assay for detection of circulating Pneumocystis antigen. None of these assays was helpful in the diagnosis of P. carinii pneumonia. An improved assay for antigenemia is needed to differentiate between clinical and subclinical infection.
使用68例获得性免疫缺陷综合征患者和135名对照的血清，来评估间接免疫荧光法和酶联免疫吸附测定法检测卡氏肺孢子虫抗体的情况，以及对流免疫电泳法检测循环卡氏肺孢子虫抗原的情况。这些检测方法均无助于卡氏肺孢子虫肺炎的诊断。需要一种改进的抗原血症检测方法来区分临床感染和亚临床感染。
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