Karami Mohammad, Ehsanivostacolaee Simin, Moazedi Ali Ahmad, Nosrati Anahita
Department of Toxicopharmacology, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Physiology, Mazandaran University of Medical Sciences, Sari, Iran.
Health Promot Perspect. 2013 Dec 31;3(2):242-5. doi: 10.5681/hpp.2013.027. eCollection 2013.
In this study the effect of zinc chloride (ZnCl2) administration on the short-term and long-term memory of rats were assessed.
We enrolled six groups of adult female and control group of eight Wistar rats in each group. One group was control group with free access to food and water, and five groups drunk zinc chloride in different doses (20, 30, 50, 70 and 100 mg/kg/day) in drinking water for two weeks during lactation .One month after birth, a shuttle box used to short- term and long-term memory and the latency in entering the dark chamber as well.
This experiment showed that maternal 70 mg/kg dietary zinc during lactation influenced the working memory of rats' offspring in all groups. Rats received 100 mg/kg/day zinc during lactation so they had significant impairment in working memory (short-term) of their offspring (P<0.05). There was no significant difference in reference (long-term) memory of all groups.
Drug consumption below70 mg/kg/day zinc chloride during lactation had no effect. While enhanced 100 mg/ kg/ day zinc in lactating rats could cause short-term memory impairment.
本研究评估了给予大鼠氯化锌（ZnCl2）对其短期和长期记忆的影响。
我们选取了六组成年雌性大鼠，每组八只，设对照组。一组为自由获取食物和水的对照组，五组在哺乳期的两周内通过饮用水摄入不同剂量（20、30、50、70和100毫克/千克/天）的氯化锌。出生后一个月，使用穿梭箱测试短期和长期记忆以及进入暗箱的潜伏期。
该实验表明，哺乳期母体饮食中70毫克/千克的锌影响了所有组大鼠后代的工作记忆。哺乳期接受100毫克/千克/天锌的大鼠，其后代的工作记忆（短期）有显著损害（P<0.05）。所有组的参考（长期）记忆无显著差异。
哺乳期氯化锌摄入量低于70毫克/千克/天无影响。而哺乳期大鼠锌摄入量增加至100毫克/千克/天会导致短期记忆受损。
