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喹喔啉叠氮基和氨基反向核糖呋喃糖苷及其O-区域异构体的合成。

Synthesis of quinoxaline azido and amino reverse ribofuranoside and their O-regioisomers.

作者信息

Ali Ibrahim A I

机构信息

a Department of Chemistry, Faculty of Science , Suez Canal University , Ismailia , Egypt.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2014;33(3):129-40. doi: 10.1080/15257770.2014.880474.

DOI:10.1080/15257770.2014.880474
PMID:24689845
Abstract

A series of quinoxaline azido reverse nucleosides 3a-c and their O-regioisomers 4a-c was prepared by reaction of quinoxaline 1a-c with 3-azido-3-deoxy-1,2-O-isopropylidene-5-p-toluenesulfonyl-D-ribofuranose (2) in the presence of sodium hydride. Structure modification of these interesting structures includes reduction and the subsequent acetylation reactions to give quinoxaline amino and acetyl amino reverse nucleosides and their O-regioisomers.

摘要

通过喹喔啉1a - c与3 - 叠氮基 - 3 - 脱氧 - 1,2 - O - 异丙叉基 - 5 - 对甲苯磺酰基 - D - 核糖呋喃糖（2）在氢化钠存在下反应，制备了一系列喹喔啉叠氮基反向核苷3a - c及其O - 区域异构体4a - c。这些有趣结构的结构修饰包括还原反应以及随后的乙酰化反应，以得到喹喔啉氨基和乙酰氨基反向核苷及其O - 区域异构体。

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