Ebead Abdelaziz, Fournier Rene, Lee-Ruff Edward
Department of Chemistry, York University, Toronto, Ontario, Canada.
Nucleosides Nucleotides Nucleic Acids. 2011 Jun;30(6):391-404. doi: 10.1080/15257770.2011.584513.
2-(6-Chloropurinyl)-3-benzoyloxymethylcyclobutanone can be prepared by reaction of 6-chloropurine with 3-benzoyloxymethyl-2-bromocyclobutanone. The N-alkylation gave both N-9 and N-7 regioisomers. Both regioisomers upon hydride reduction followed by aminolysis gave the corresponding adenine nucleoside analogues. However, the N-7 series led to the hypoxanthine analogues as byproducts.
2-(6-氯嘌呤基)-3-苯甲酰氧基甲基环丁酮可通过6-氯嘌呤与3-苯甲酰氧基甲基-2-溴环丁酮反应制备。N-烷基化反应生成了N-9和N-7区域异构体。两种区域异构体经氢化物还原后再进行氨解，得到了相应的腺嘌呤核苷类似物。然而，N-7系列反应产生了次黄嘌呤类似物作为副产物。
