食用全谷物和豆类可以调节 APOA5-1131C 变异体的遗传效应，从而改变空腹血糖受损或新诊断为 2 型糖尿病患者的甘油三酯和载脂蛋白 A-V 浓度的变化。
Consumption of whole grains and legumes modulates the genetic effect of the APOA5 -1131C variant on changes in triglyceride and apolipoprotein A-V concentrations in patients with impaired fasting glucose or newly diagnosed type 2 diabetes.
机构信息
Department of Food and Nutrition, College of Human Ecology, National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea.
出版信息
Trials. 2014 Apr 1;15:100. doi: 10.1186/1745-6215-15-100.
BACKGROUND
The apolipoprotein A5 gene (APOA5) -1131 T > C polymorphism is associated with mild hypertriglyceridemia in type 2 diabetic subjects, and interacts with dietary fat in the determination of triglyceride concentrations. We examined whether a substitution of whole grains and legumes for refined rice in a high carbohydrate diet (about 65% of energy derived from carbohydrate) may modify the effect of this variant on changes in apolipoprotein A-V (apoA-V) and triglyceride concentrations.
METHODS
We genotyped the APOA5 -1131 T > C in individuals with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes, who were randomly assigned to either a group ingesting whole grain and legume meals daily or a control group for 12 weeks.
RESULTS
After dietary intervention, we observed significant interactions between the APOA5 -1131 T > C polymorphism and carbohydrate sources (whole grains and legumes versus refined rice) in the determination of mean percent changes in triglyceride and apoA-V (P interactions <0.001 and =0.038, respectively). In the refined rice group (n = 93), the carriers of the risk C allele (n = 50) showed a greater increase in the mean percent changes of triglyceride and apoA-V than noncarriers after adjusting for HOMA-IR (P = 0.004 and 0.021, respectively). The whole grain and legume group (n = 92), however, showed a decrease in fasting glucose, HOMA-IR, and triglyceride, and an increase in apoA-V, irrespective of genotype.
CONCLUSIONS
The data showed that the magnitude of the genetic effect of the APOA5 -1131C variant on triglyceride and apoA-V levels was modulated when substituting consumption of whole grains and legumes for refined rice as a carbohydrate source in IFG or diabetic subjects.
TRIAL REGISTRATION
ClinicalTrials.gov: NCT01784952.
背景
载脂蛋白 A5 基因（APOA5）-1131T>C 多态性与 2 型糖尿病患者的轻度高甘油三酯血症有关，并且与饮食脂肪相互作用，共同决定甘油三酯浓度。我们研究了在高碳水化合物饮食（约 65%的能量来自碳水化合物）中用全谷物和豆类代替精制米是否可以改变这种变体对载脂蛋白 A-V（apoA-V）和甘油三酯浓度变化的影响。
方法
我们对空腹血糖受损（IFG）或新诊断的 2 型糖尿病患者进行了 APOA5-1131T>C 基因分型，他们被随机分配到每天摄入全谷物和豆类膳食的组或对照组，进行 12 周的干预。
结果
在饮食干预后，我们观察到 APOA5-1131T>C 多态性与碳水化合物来源（全谷物和豆类与精制米）之间存在显著的相互作用，共同决定了甘油三酯和 apoA-V 的平均百分比变化（P 交互<0.001 和=0.038，分别）。在精制米组（n=93）中，风险 C 等位基因携带者（n=50）在调整 HOMA-IR 后，甘油三酯和 apoA-V 的平均百分比变化增加更大（P=0.004 和 0.021，分别）。然而，全谷物和豆类组（n=92）无论基因型如何，均显示空腹血糖、HOMA-IR 和甘油三酯降低，apoA-V 升高。
结论
数据表明，当用全谷物和豆类代替精制米作为 IFG 或糖尿病患者的碳水化合物来源时，APOA5-1131C 变体对甘油三酯和 apoA-V 水平的遗传效应的幅度发生了调节。
试验注册
ClinicalTrials.gov：NCT01784952。
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