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人正常、增生及癌性前列腺组织对表皮生长因子的结合

Binding of epidermal growth factor by human normal, hypertrophic, and carcinomatous prostate.

作者信息

Davies P, Eaton C L

机构信息

Tenovus Institute for Cancer Research, University of Wales College of Medicine, Cardiff, United Kingdom.

出版信息

Prostate. 1989;14(2):123-32. doi: 10.1002/pros.2990140206.

DOI:10.1002/pros.2990140206
PMID:2469072
Abstract

Saturable binding sites for radioiodinated epidermal growth factor (EGF) have been quantified in surgical specimens of benign prostate hypertrophy (BPH), histologically normal (HN) prostate, and prostate cancer. Values for EGF binding did not differ significantly between HN prostate and prostate cancer, although dedifferentiated samples tended to higher levels. These were coincident with lower comparative levels of androgen receptors. Unfractionated BPH tissue contained lower levels of EGF binding than either HN or carcinomatous prostate, but in separated epithelial cells EGF binding fell into the same range. Saturation analyses showed two affinity classes of binding in all except dedifferentiated tissues.

摘要

已对良性前列腺增生（BPH）、组织学正常（HN）前列腺及前列腺癌的手术标本中放射性碘化表皮生长因子（EGF）的可饱和结合位点进行了定量分析。尽管去分化样本的EGF结合水平往往较高，但HN前列腺和前列腺癌之间的EGF结合值并无显著差异。这些与雄激素受体的较低比较水平相一致。未分级的BPH组织中EGF结合水平低于HN前列腺或癌性前列腺，但在分离的上皮细胞中，EGF结合水平处于相同范围。饱和分析表明，除去分化组织外，所有组织中的结合均有两种亲和力类型。

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