理解组织背景对肿瘤异质性的影响。
Understanding tissue context influences on intratumour heterogeneity.
机构信息
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02215, USA.
Center for Bioengineering and Tissue Regeneration and Departments of Surgery, Anatomy, Bioengineering and Therapeutics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Helen Diller Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.
出版信息
Nat Cell Biol. 2014 Apr;16(4):301-2. doi: 10.1038/ncb2942.
Abstract
Although human cancers exhibit intratumour heterogeneity, the influence of the tumour environment on this property is unclear. Single basal-like mammary epithelial cells are now shown to engage a dynamic TGFBR3-JUND signalling circuit in an extracellular-matrix-dependent manner. Cell transition between the distinct gene expression states underlying this circuit alters their properties and may modulate their propensity to malignancy.
摘要
尽管人类癌症表现出肿瘤内异质性，但肿瘤微环境对其的影响尚不清楚。现在发现，单个基底样乳腺上皮细胞以细胞外基质依赖的方式激活一个动态的 TGFBR3-JUND 信号通路。该通路所依赖的不同基因表达状态下的细胞转换改变了它们的特性，并可能调节它们的恶性倾向。
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本文引用的文献
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A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies.在单个乳腺上皮细胞和基底样癌前病变中，存在一个时空调控的 TGFBR3-JUND-KRT5 调控回路。
Nat Cell Biol. 2014 Apr;16(4):345-56. doi: 10.1038/ncb2930. Epub 2014 Mar 23.
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