Grönwall Caroline, Silverman Gregg J
Department of Medicine, New York University School of Medicine, New York, NY, 10016, USA,
J Clin Immunol. 2014 Jul;34 Suppl 1(0 1):S12-21. doi: 10.1007/s10875-014-0025-4. Epub 2014 Apr 2.
Natural IgM are highly represented in the circulation at birth, and these often autoreactive antibodies have been postulated to have innate-like properties and play crucial roles in apoptotic cell clearance, tissue homeostasis, and immune modulation. This review summarizes the known properties of these IgM autoantibodies, and the evidence that these anti-apoptotic cell IgM natural antibodies can regulate inflammatory responses through ancient pathways of the innate immune system that first arose long before the initial emergence of the adaptive immune system. While the regulatory contributions of these natural IgM autoantibodies are certainly not an essential and fundamental component of host defenses, these provide an additional layer to further protect the host. More importantly, these IgM antibody responses are highly inducible and their up-regulation can be a powerful means for the host to survive in a setting of chronic inflammation. The observed beneficial clinical associations for cardiovascular disease and autoimmunity, as well as opportunities for potential therapeutic implications are discussed.
天然IgM在出生时在循环系统中大量存在，这些通常具有自身反应性的抗体被认为具有类似先天免疫的特性，并在凋亡细胞清除、组织稳态和免疫调节中发挥关键作用。本综述总结了这些IgM自身抗体的已知特性，以及这些抗凋亡细胞IgM天然抗体可通过早在适应性免疫系统最初出现之前就已存在的先天免疫系统古老途径调节炎症反应的证据。虽然这些天然IgM自身抗体的调节作用肯定不是宿主防御的基本组成部分，但它们为进一步保护宿主提供了额外的一层保护。更重要的是，这些IgM抗体反应具有高度可诱导性，其上调可能是宿主在慢性炎症环境中生存的有力手段。本文还讨论了观察到的与心血管疾病和自身免疫相关的有益临床关联以及潜在治疗意义的机会。
