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简并性的利弊。

The pros and cons of degeneracy.

作者信息

Goaillard Jean-Marc, Dufour Martial A

机构信息

Jean-Marc Goaillard is at Inserm (Inserm UMR_S 1072) and Aix Marseille University, Marseille, France

出版信息

Elife. 2014 Apr 1;3:e02615. doi: 10.7554/eLife.02615.

DOI:10.7554/eLife.02615
PMID:24692452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3970757/
Abstract

Drugs could treat neuropathic pain more effectively if they simultaneously targeted two or more types of ion channel.

摘要

如果药物能同时作用于两种或更多类型的离子通道，那么它们就能更有效地治疗神经性疼痛。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee2b/3970757/6c33d5338304/elife02615f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee2b/3970757/6c33d5338304/elife02615f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee2b/3970757/6c33d5338304/elife02615f001.jpg

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本文引用的文献

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Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain.原发性传入神经兴奋性损伤诱导变化中的临界性与退化及其对神经性疼痛的影响
Elife. 2014 Apr 1;3:e02370. doi: 10.7554/eLife.02370.
2
Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy.外显子组测序离子通道基因揭示了复杂的模式，混淆了癫痫患者的个人风险评估。
Cell. 2011 Jun 24;145(7):1036-48. doi: 10.1016/j.cell.2011.05.025.
3
Multiple models to capture the variability in biological neurons and networks.
神经元对多种特性进行共调节的最小要求，以及对离子通道相关性和鲁棒性的影响。
Elife. 2022 Mar 16;11:e72875. doi: 10.7554/eLife.72875.
4
Neuronal population models reveal specific linear conductance controllers sufficient to rescue preclinical disease phenotypes.神经元群体模型揭示了足以挽救临床前疾病表型的特定线性电导控制器。
iScience. 2021 Oct 14;24(11):103279. doi: 10.1016/j.isci.2021.103279. eCollection 2021 Nov 19.
5
Ling's Adsorption Theory as a Mechanism of Membrane Potential Generation Observed in Both Living and Nonliving Systems.作为在生物和非生物系统中均观察到的膜电位产生机制的林氏吸附理论。
Membranes (Basel). 2016 Jan 26;6(1):11. doi: 10.3390/membranes6010011.
6
Dynamic Input Conductances Shape Neuronal Spiking.动态输入电导塑造神经元发放。
eNeuro. 2015 Mar 25;2(1). doi: 10.1523/ENEURO.0031-14.2015. eCollection 2015 Jan-Feb.
7
Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus.KCNQ2/3和HCN通道的噪声诱导可塑性是耳鸣易感性和恢复力的基础。
Elife. 2015 Aug 27;4:e07242. doi: 10.7554/eLife.07242.
捕捉生物神经元和网络变异性的多种模型。
Nat Neurosci. 2011 Feb;14(2):133-8. doi: 10.1038/nn.2735.
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Sodium channels in normal and pathological pain.正常和病理性疼痛中的钠离子通道。
Annu Rev Neurosci. 2010;33:325-47. doi: 10.1146/annurev-neuro-060909-153234.
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Neuropathic pain: a maladaptive response of the nervous system to damage.神经性疼痛：神经系统对损伤的一种适应性不良反应。
Annu Rev Neurosci. 2009;32:1-32. doi: 10.1146/annurev.neuro.051508.135531.
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