Transganglionic regulation of primary sensory neurons.

Structural and functional properties of central terminals of primary sensory neurons are regulated by nerve growth factor supplied by retrograde axoplasmic transport to dorsal root ganglion cells. Two important aspects of this regulatory system: transganglionic degenerative atrophy and regenerative synaptoneogenesis are reviewed in view of electron histochemical, electrophysiological and clinical studies performed during the last decade in the authors' laboratory and abroad.