Csillik B, Knyihár-Csillik E
Neuroscience. 1982 May;7(5):1149-54. doi: 10.1016/0306-4522(82)91122-8.
Microtubule inhibitor Vinca alkaloids applied around a peripheral nerve induce transganglionic degenerative atrophy of the central terminals of primary nociceptive neurons. This effect is reversible: 40-50 days later the original histochemical structure of the central terminals is restored. Restoration of fluoride-resistant acid phosphatase activity (the marker enzyme of primary nociceptive neurons) in the Rolando substance is due to regenerative sprouting of the formerly atrophied central terminals. Since peripherally-applied Vinca alkaloids induce transganglionic degenerative atrophy of the central terminals without inducing Wallerian degeneration of the peripheral nerve, and since this effect (virtually a synaptic uncoupling) is only temporary, this approach may be used in the treatment of otherwise intractable neuralgias without inducing irreparable alterations.
在周围神经周围应用微管抑制剂长春花生物碱会诱导初级伤害性神经元中枢终末的跨神经节变性萎缩。这种效应是可逆的：40 - 50天后，中枢终末的原始组织化学结构得以恢复。罗兰多质中耐氟酸性磷酸酶活性（初级伤害性神经元的标记酶）的恢复是由于先前萎缩的中枢终末的再生性发芽。由于外周应用长春花生物碱会诱导中枢终末的跨神经节变性萎缩，而不会诱导周围神经的瓦勒变性，并且由于这种效应（实际上是一种突触解偶联）只是暂时的，所以这种方法可用于治疗其他难以治疗的神经痛，而不会引起不可修复的改变。
