维生素C对继发性甲状旁腺功能亢进血液透析患者甲状旁腺激素的影响：一项双盲、安慰剂对照研究。

The effect of vitamin C on parathyroid hormone in patients on hemodialysis with secondary hyperparathyroidism: a double blind, placebo-controlled study.

作者信息

Biniaz Vajihe, Nemati Eghlim, Tayebi Ali, Sadeghi Shermeh Mehdi, Ebadi Abbas

机构信息

Department of Medical Surgical Nursing, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

Nephrology and Urology Department, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

出版信息

Nephrourol Mon. 2013 Nov;5(5):962-6. doi: 10.5812/numonthly.12404. Epub 2013 Nov 13.

DOI:10.5812/numonthly.12404

PMID:24693502

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3955287/

Abstract

BACKGROUND

Secondary hyperparathyroidism (SHPT) is a prevalent disorder in patients with chronic kidney disease. It is proffered that there is a contradictory relation between serum level of vitamin C and parathyroid hormone (PTH) in hemodialysis patients with secondary hyperparathyroidism.

OBJECTIVES

The goal of this study was to assess the effects of the supplemental vitamin C on parathyroid hormone among hemodialysis patients with secondary hyperparathyroidism.

PATIENTS AND METHODS

This randomized, placebo-controlled, double-blind and parallel-group trial was conducted on 82 hemodialysis patients with serum levels of PTH more than 200 pg/mL. In intervention group, 250 mg vitamin C was injected three times a week for 8 weeks in a row immediately at the end of each dialysis session via the intravenous route. In the control group, same term of placebo saline was injected.

RESULTS

The mean of serum PTH was 699.81 (± 318.8) and 596.03 (± 410.7) pg/mL in intervention and control groups respectively at baseline (reference range, 6 to 66 pg/mL), and at the end of study it changed to 441.4 and 424.6 in these groups. The values of serum Calcium and Phosphate did not significantly change during the study (8.4 ± 0.6 mg/dL versus 8.1 ± 0.8 mg/dL, P = 0.39; 5.89 ± 1.7 mg/dL versus 5.9 ± 1.9 mg/dL, P = 0.08, respectively).

CONCLUSIONS

This study finding does not warranted therapeutic effect of vitamin C on secondary hyperparathyroidism.

摘要

背景

继发性甲状旁腺功能亢进（SHPT）是慢性肾病患者中一种普遍存在的病症。有人提出，在患有继发性甲状旁腺功能亢进的血液透析患者中，血清维生素C水平与甲状旁腺激素（PTH）之间存在矛盾关系。

目的

本研究的目的是评估补充维生素C对继发性甲状旁腺功能亢进血液透析患者甲状旁腺激素的影响。

患者与方法

本随机、安慰剂对照、双盲和平行组试验针对82名血清PTH水平超过200 pg/mL的血液透析患者进行。在干预组中，在每次透析结束时立即通过静脉途径连续8周每周三次注射250 mg维生素C。在对照组中，注射相同疗程的安慰剂生理盐水。

结果

干预组和对照组在基线时血清PTH的平均值分别为699.81（±318.8）和596.03（±410.7）pg/mL（参考范围为6至66 pg/mL），在研究结束时，这些组中的值分别变为441.4和424.6。在研究期间，血清钙和磷的值没有显著变化（分别为8.4±0.6 mg/dL对8.1±0.8 mg/dL，P = 0.39；5.89±1.7 mg/dL对5.9±1.9 mg/dL，P = 0.08）。