Makiyama Hiroaki, Kataoka Ryoko, Tauchi Masaru, Sumitomo Hiroki, Fuita Rikiya
Gastroenterological Center, Yokohama Shin-midori General Hospital, Japan.
Intern Med. 2014;53(7):691-4. doi: 10.2169/internalmedicine.53.1789. Epub 2012 Mar 1.
We herein report two cases of portal venous gas (PVG) following alpha-glucosidase inhibitor (α-GI) therapy for diabetes mellitus. Anti-diabetic treatment with voglibose was commenced in the first case, while the second case was treated with miglitol. Both patients recovered without intensive treatment after discontinuing the α-GI therapy. α-GI medications may increase internal intestinal tract pressure by releasing carbon dioxide and hydrogen gas, potentially causing pneumatosis cystoides intestinalis (PCI) or PVG. Our experience suggests that α-GI therapy is an important potential cause of portal venous gas that can be treated conservatively.
我们在此报告两例糖尿病患者在接受α-葡萄糖苷酶抑制剂（α-GI）治疗后出现门静脉气体（PVG）的病例。第一例患者开始使用伏格列波糖进行抗糖尿病治疗，第二例患者使用米格列醇治疗。在停用α-GI治疗后，两名患者均未经过强化治疗就康复了。α-GI药物可能通过释放二氧化碳和氢气增加肠道内压力，从而可能导致小肠气囊肿（PCI）或PVG。我们的经验表明，α-GI治疗是门静脉气体的一个重要潜在原因，可采用保守治疗。
