Kojima Kuniyuki, Tsujimoto Tatsuhiro, Fujii Hisao, Morimoto Tomoko, Yoshioka Seisaku, Kato Saki, Yasuhara Yumi, Aizawa Shigeyuki, Sawai Mizuho, Makutani Shiro, Yamamoto Koji, Mochi Tadao, Fukui Hiroshi
Department of Internal Medicine, Hattori Memorial Hospital, Nara.
Intern Med. 2010;49(15):1545-8. doi: 10.2169/internalmedicine.49.3634. Epub 2010 Aug 2.
Pneumatosis cystoides intestinalis (PCI) is a rare condition in which pneumocysts develop in the submucosa or subserosa of the colon. We report herein a case of PCI induced by the alpha-glucosidase inhibitor (alphaGI) miglitol. There have been 9 recorded cases of PCI induced by other alphaGIs, but this is the first report of miglitol causing PCI. The PCI lesions in our case were smaller than those induced by voglibose or acarbose. The possibility of PCI should be considered in diabetic patients on alphaGI therapy who complain of gastrointestinal symptoms, and the gastrointestinal tract should be thoroughly investigated in these patients.
肠壁囊样积气症（PCI）是一种罕见病症，其中结肠黏膜下层或浆膜下层会出现肺囊肿。我们在此报告一例由α-葡萄糖苷酶抑制剂（αGI）米格列醇诱发的PCI病例。此前已有9例由其他αGI诱发PCI的记录病例，但这是米格列醇导致PCI的首例报告。我们病例中的PCI病变比伏格列波糖或阿卡波糖诱发的病变更小。对于接受αGI治疗且出现胃肠道症状的糖尿病患者，应考虑PCI的可能性，并应对这些患者的胃肠道进行全面检查。
