1School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, AUSTRALIA; 2Edith Cowan University Health and Wellness Institute, Edith Cowan University, Joondalup, Western Australia, AUSTRALIA; 3School of Environmental and Life Sciences, University of Newcastle, Ourimbah, New South Wales, AUSTRALIA; 4School of Human Movement Studies, University of Queensland, Brisbane, Queensland, AUSTRALIA; 5Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, AUSTRALIA; and 6Faculty of Medicine, University of Western Australia, Nedlands, Western Australia, AUSTRALIA.
Med Sci Sports Exerc. 2014 Dec;46(12):2210-5. doi: 10.1249/MSS.0000000000000353.
Exercise is being increasingly established as a key adjuvant therapy in clinical oncology. As research has demonstrated the beneficial effect of exercise for cancer management, a growing number of patients with cancer are undertaking structured exercise programs.
This study aimed to determine the safety and feasibility of formal exercise testing in clinical settings as it is becoming increasingly used as a screening tool and for exercise prescription purposes.
One hundred and twelve patients with prostate cancer undergoing androgen deprivation therapy (ADT) took part in a physician-supervised multistage maximal stress test (Bruce protocol). Sixty patients had been on ADT for <3 months (acute), whereas 52 had been on ADT for >3 months (chronic).
Of these men, 85% were able to meet the criteria for the attainment of V˙O2max, whereas three positive tests (3.2%) were observed. The three participants who recorded a positive stress test underwent further medical examination and were subsequently cleared of clinically significant cardiovascular disease. Apart from the relatively low V˙O2max (24.7 ± 6.0 mL·kg·min, 10th-15th percentile), compared with normative data in healthy age-matched controls, the cardiovascular response to exercise was similar in this cancer population. Moreover, treatment duration did not seem to influence cardiovascular responses to exercise. This early evidence suggests that risk of adverse events during maximal exercise testing is relatively low in this population and certainly no higher than that in ages-matched, apparently healthy individuals.
Maximal exercise testing was demonstrated to be feasible and safe, providing a direct assessment of V˙O2max. The relatively low number of positive tests in this study suggests that the risk of adverse events is relatively low in this population and certainly no higher than that in age-matched, apparently healthy individuals.
运动越来越被确立为临床肿瘤学的主要辅助治疗方法。随着研究表明运动对癌症管理的有益影响，越来越多的癌症患者正在进行结构化的运动计划。
本研究旨在确定在临床环境中进行正式运动测试的安全性和可行性，因为它越来越多地被用作筛查工具和运动处方的目的。
112 名接受雄激素剥夺治疗（ADT）的前列腺癌患者参加了医生监督的多阶段最大应激测试（Bruce 方案）。60 名患者 ADT 时间<3 个月（急性），52 名患者 ADT 时间>3 个月（慢性）。
这些男性中，85%能够达到 V˙O2max 的标准，而观察到 3 次阳性测试（3.2%）。记录阳性应激测试的 3 名参与者接受了进一步的医学检查，随后被清除了临床上明显的心血管疾病。除了相对较低的 V˙O2max（24.7±6.0 mL·kg·min，10-15%）与健康年龄匹配对照组的正常数据相比，该癌症人群的心血管对运动的反应相似。此外，治疗持续时间似乎并未影响心血管对运动的反应。这些早期证据表明，在该人群中，最大运动测试期间发生不良事件的风险相对较低，并且肯定不比年龄匹配的、明显健康个体高。
最大运动测试被证明是可行和安全的，可直接评估 V˙O2max。本研究中阳性测试的相对较少数量表明，在该人群中发生不良事件的风险相对较低，并且肯定不比年龄匹配的、明显健康个体高。
