Yen Chia-Jui, Hung Ching-Hsia, Tsai Wei-Ming, Cheng Hui-Ching, Yang Hsin-Lun, Lu Yan-Jhen, Tsai Kun-Ling
Division of Hematology and Oncology, Department of Internal Medicine, Graduate Institute of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Front Oncol. 2020 Aug 18;10:1536. doi: 10.3389/fonc.2020.01536. eCollection 2020.
Chemotherapy decreases fitness performance via repression of cardiopulmonary function and oxidative stress. This study was designed to investigate whether exercise intervention could improve exercises capacity and reduce systemic oxidative stress in patients with head and neck (H&N) cancer receiving chemotherapy.
This is a single-center study. Forty-two H&N cancer patients who were undergoing chemotherapy were recruited in this study. An 8-week exercise intervention was performed by conducting the combination of aerobic and resistance exercise 3 days a week. The exercise training was conducted by a physiotherapist. The exercise capacity and exercise responses were measured from blood pressure (BP) and heart rate (HR). Oxidative stress markers from human plasma, such as total antioxidant capacity, 8-hydroxy-2'-deoxyguanosine, malondialdehyde, and carbonyl content, were tested by activity kits.
We provide compelling evidence that exercise training ameliorated exercise responses and increased exercise capacity by repressing resting BP and increasing 1- and 3-min BP recovery. We also found the resting HR was reduced, and the 1- and 3-min HR recovery was increased after exercise training. In addition, the rating of perceived exertion after the peak exercise was reduced after exercise intervention. We also found that exercise training repressed oxidative stress markers by elevation of total antioxidant capacity and suppression of 8-OHd and carbonyl content in plasma.
We clearly demonstrate that exercise can promote exercise capacity and reduce oxidative stress in H&N cancer patients receiving chemotherapy, which might guide new therapeutic approaches for cancer patients, especially those undergoing chemotherapy.
化疗通过抑制心肺功能和氧化应激降低体能表现。本研究旨在调查运动干预是否能改善接受化疗的头颈癌患者的运动能力并减轻全身氧化应激。
这是一项单中心研究。本研究招募了42名正在接受化疗的头颈癌患者。通过每周3天进行有氧运动和抗阻运动相结合的方式进行为期8周的运动干预。运动训练由一名物理治疗师进行。通过测量血压（BP）和心率（HR）来评估运动能力和运动反应。使用活性试剂盒检测人血浆中的氧化应激标志物，如总抗氧化能力、8-羟基-2'-脱氧鸟苷、丙二醛和羰基含量。
我们提供了有力证据表明，运动训练通过降低静息血压和提高1分钟及3分钟血压恢复能力改善了运动反应并提高了运动能力。我们还发现运动训练后静息心率降低，1分钟及3分钟心率恢复能力提高。此外，运动干预后运动峰值时的主观用力程度评分降低。我们还发现运动训练通过提高总抗氧化能力以及抑制血浆中8-OHd和羰基含量来抑制氧化应激标志物。
我们清楚地证明，运动可以提高接受化疗的头颈癌患者的运动能力并减轻氧化应激，这可能为癌症患者，尤其是正在接受化疗的患者，指引新的治疗方法。
