Kuang Dan, Chen Wei, Song Yue-Zhang, Yu Yan-Yan, Zhang Dong-Ying, Wu Lang, Tang Jie
Chengdu Municipal Center for Disease Control and Prevention, Chengdu, China E-mail :
Asian Pac J Cancer Prev. 2014;15(16):6855-61. doi: 10.7314/apjcp.2014.15.16.6855.
Previous epidemiological studies have suggested a potential role of the HSPA1B±1267A/G polymorphism in risk of developing cancer. However, the results were inconsistent. Therefore, we performed this meta-analysis to summarize the possible association with cancer risk.
We retrieved relevant articles from PubMed, EMBASE, ISI Web of Science, Chinese Biomedical Literature and Chinese National Knowledge Infrastructure. Studies were selected using specific criteria. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess those associations. All analyses were performed using STATA software.
Fourteen case-control studies, including 1, 834 cancer cases and 2, 028 controls were included in this meta-analysis. Overall, the results indicated that the G allele of HSPA1B gene ±1267A/G was significantly associated with an increased cancer risk in all genetic models (G vs A: OR=1.51, 95%CI 1.17-1.95, p=0.001; GG vs AA: OR=2.93, 95%CI 1.50-5.74, p=0.002; AG vs AA: OR=1.48, 95%CI 1.10-1.98, p=0.009; GG/AG vs AA: OR=1.69, 95%CI 1.22-2.33, p=0.001; GG vs
AG/AA: OR=2.31, 95%CI 1.24-4.32, p=0.009). In the subgroup analysis stratified by ethnicity, a significant association was identified in Caucasians (G vs A: OR=1.35, 95%CI 1.08-1.69, p=0.008; GG/AG vs AA: OR=1.36, 95%CI 1.09-1.70, p=0.007), but not in Asians. In the stratified analysis by cancer types, individuals with the G allele showed an increased risk of hepatocellular carcinoma compared with carriers of the A allele (OR=2.40, 95%CI 1.47-3.91, p< 0.001). Inversely, individuals with the GG genotype showed a decreased risk of gastric cancer compared with carriers of the AG/GG genotypes (GG vs
AG/AA: OR=0.39, 95%CI 0.20-0.70, p=0.007).
This meta-analysis suggests associations between the HSPA1B ±1267A/G polymorphism and risk of cancer. However, this association might be Caucasian-specific and the G allele of this polymorphism probably increases risk of hepatocellular carcinoma while decreasing risk of gastric cancer. Further well-designed studies based on larger sample sizes are needed to validate these findings.
既往流行病学研究提示HSPA1B基因±1267A/G多态性在癌症发生风险中可能发挥作用。然而，研究结果并不一致。因此，我们进行了这项荟萃分析以总结其与癌症风险的可能关联。
我们从PubMed、EMBASE、ISI科学网、中国生物医学文献数据库和中国知网检索相关文章。采用特定标准选择研究。计算比值比（OR）及95%置信区间（CI）以评估这些关联。所有分析均使用STATA软件进行。
本荟萃分析纳入了14项病例对照研究，包括1834例癌症病例和2028例对照。总体而言，结果表明HSPA1B基因±1267A/G的G等位基因在所有遗传模型中均与癌症风险增加显著相关（G vs A：OR = 1.51，95%CI 1.17 - 1.95，p = 0.001；GG vs AA：OR = 2.93，95%CI 1.50 - 5.74，p = 0.002；AG vs AA：OR = 1.48，95%CI 1.10 - 1.98，p = 0.009；GG/AG vs AA：OR = 1.69，95%CI 1.22 - 2.33，p = 0.001；GG vs AG/AA：OR = 2.31，95%CI 1.24 - 4.32，p = 0.009）。在按种族分层的亚组分析中，在白种人中发现了显著关联（G vs A：OR = 1.35，95%CI 1.08 - 1.69，p = 0.008；GG/AG vs AA：OR = 1.36，95%CI 1.09 - 1.70，p = 0.007），而在亚洲人中未发现。在按癌症类型分层的分析中，与A等位基因携带者相比，携带G等位基因的个体患肝细胞癌的风险增加（OR = 2.40，95%CI 1.47 - 3.91，p < 0.001）。相反，与AG/GG基因型携带者相比，GG基因型个体患胃癌的风险降低（GG vs AG/AA：OR = 0.39）
