Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.
Evid Based Complement Alternat Med. 2014;2014:954863. doi: 10.1155/2014/954863. Epub 2014 Feb 18.
Aspirin plays a crucial physiological and pathophysiological role in cardiovascular diseases and cerebrovascular diseases by irreversibly inhibiting thromboxane A2. However, some patients may be "resistant" to its effect. The resistance has close association with adverse cardiovascular outcomes and increased mortality, so that resolving the problem of aspirin resistance (AR) is widely concerned. By studying the correlation between AR and blood stasis syndrome (BSS), it is demonstrated that BSS may be one of the pathogenesis of AR in traditional Chinese medicine. Chinese herb and formulas definitely possess the advantage of whole body regulation by many ways and many targets. It is a new direction for treatment of AR to combine TCM and modern medicine to study the mechanism and prevention of AR.
阿司匹林通过不可逆地抑制血栓素 A2 在心血管疾病和脑血管疾病中发挥着至关重要的生理和病理生理作用。然而，一些患者可能对其效果“产生抵抗”。这种抵抗与不良心血管结局和死亡率增加密切相关，因此解决阿司匹林抵抗（AR）问题受到广泛关注。通过研究 AR 与血瘀证（BSS）之间的相关性，表明 BSS 可能是 AR 的中医发病机制之一。中药和方剂通过多种途径和多个靶点肯定具有整体调节的优势。将中医和现代医学相结合，研究 AR 的机制和预防，是治疗 AR 的一个新方向。
