Department of Cardiovascular and Neurologic Disease, College of Oriental Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea.
Evid Based Complement Alternat Med. 2012;2012:696983. doi: 10.1155/2012/696983. Epub 2012 May 31.
Blood stasis syndrome (BSS) in traditional Asian medicine has been considered to correlate with the extent of atherosclerosis, which can be estimated using the cardioankle vascular index (CAVI). Here, the diagnostic utility of CAVI in predicting BSS was examined. The BSS scores and CAVI were measured in 140 stroke patients and evaluated with respect to stroke risk factors. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic accuracy of CAVI for the diagnosis of BSS. The BSS scores correlated significantly with CAVI, age, and systolic blood pressure (SBP). Multiple logistic regression analysis showed that CAVI was a significant associate factor for BSS (OR 1.55, P = 0.032) after adjusting for the age and SBP. The ROC curve showed that CAVI and age provided moderate diagnostic accuracy for BSS (area under the ROC curve (AUC) for CAVI, 0.703, P < 0.001; AUC for age, 0.692, P = 0.001). The AUC of the "CAVI+Age," which was calculated by combining CAVI with age, showed better accuracy (0.759, P < 0.0001) than those of CAVI or age. The present study suggests that the CAVI combined with age can clinically serve as an objective tool to diagnose BSS in stroke patients.
血瘀证（BSS）在传统亚洲医学中被认为与动脉粥样硬化的程度相关，而动脉粥样硬化可以通过心血管踝血管指数（CAVI）来评估。在此，我们研究了 CAVI 在预测 BSS 中的诊断效用。在 140 名中风患者中测量了 BSS 评分和 CAVI，并评估了其与中风危险因素的相关性。使用受试者工作特征（ROC）曲线分析来确定 CAVI 对 BSS 诊断的准确性。BSS 评分与 CAVI、年龄和收缩压（SBP）显著相关。多因素 logistic 回归分析显示，在调整年龄和 SBP 后，CAVI 是 BSS 的一个显著相关因素（OR 1.55，P = 0.032）。ROC 曲线显示，CAVI 和年龄对 BSS 具有中等的诊断准确性（CAVI 的 ROC 曲线下面积（AUC）为 0.703，P < 0.001；年龄的 AUC 为 0.692，P = 0.001）。通过将 CAVI 与年龄相结合计算的“CAVI+Age”的 AUC 显示出更好的准确性（0.759，P < 0.0001），优于 CAVI 或年龄。本研究表明，CAVI 与年龄相结合可以作为一种客观的工具，用于诊断中风患者的 BSS。
