Ristić-Medić Danijela, Dullemeijer Carla, Tepsić Jasna, Petrović-Oggiano Gordana, Popović Tamara, Arsić Aleksandra, Glibetić Marija, Souverein Olga W, Collings Rachel, Cavelaars Adriënne, de Groot Lisette, van't Veer Pieter, Gurinović Mirjana
Nutr Rev. 2014 Mar;72(3):143-61. doi: 10.1111/nure.12092.
The objective of this systematic review was to identify studies investigating iodine intake and biomarkers of iodine status, to assess the data of the selected studies, and to estimate dose-response relationships using meta-analysis. All randomized controlled trials, prospective cohort studies, nested case-control studies, and cross-sectional studies that supplied or measured dietary iodine and measured iodine biomarkers were included. The overall pooled regression coefficient (β) and the standard error of β were calculated by random-effects meta-analysis on a double-log scale, using the calculated intake-status regression coefficient (β) for each individual study. The results of pooled randomized controlled trials indicated that the doubling of dietary iodine intake increased urinary iodine concentrations by 14% in children and adolescents, by 57% in adults and the elderly, and by 81% in pregnant women. The dose-response relationship between iodine intake and biomarkers of iodine status indicated a 12% decrease in thyroid-stimulating hormone and a 31% decrease in thyroglobulin in pregnant women. The model of dose-response quantification used to describe the relationship between iodine intake and biomarkers of iodine status may be useful for providing complementary evidence to support recommendations for iodine intake in different population groups.
本系统评价的目的是识别调查碘摄入量和碘营养状况生物标志物的研究，评估所选研究的数据，并通过荟萃分析估计剂量反应关系。纳入所有提供或测量膳食碘并测量碘生物标志物的随机对照试验、前瞻性队列研究、巢式病例对照研究和横断面研究。使用每个个体研究计算的摄入-状态回归系数(β)，通过双对数尺度的随机效应荟萃分析计算总体合并回归系数(β)和β的标准误差。汇总随机对照试验的结果表明，膳食碘摄入量加倍使儿童和青少年的尿碘浓度增加14%，成年人和老年人增加57%，孕妇增加81%。碘摄入量与碘营养状况生物标志物之间的剂量反应关系表明，孕妇促甲状腺激素降低12%，甲状腺球蛋白降低31%。用于描述碘摄入量与碘营养状况生物标志物之间关系的剂量反应量化模型，可能有助于提供补充证据，以支持不同人群碘摄入量的建议。
