Farebrother Jessica, Naude Celeste E, Nicol Liesl, Sang Zhongna, Yang Zhenyu, Andersson Maria, Jooste Pieter L, Zimmermann Michael B
Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland.
Centre for Evidence-Based Health Care, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
BMJ Open. 2015 Apr 23;5(4):e007238. doi: 10.1136/bmjopen-2014-007238.
Iodine is an essential micronutrient and component of the thyroid hormones. Sufficient ingestion of iodine is necessary for normal growth and development. If iodine requirements are not met, growth can be impaired. Salt iodisation and supplementation with iodine can prevent iodine deficiency disorders and stunted growth. No systematic review has yet collated the evidence linking iodine to growth. With an increased emphasis on stunting within the WHO Global Nutrition Targets for 2025, we propose a systematic review to address this question.
We will undertake a systematic review, and if appropriate, meta-analyses, evaluating the effects of iodised salt or iodine supplements on prenatal and postnatal somatic growth, until age 18. We will search a number of databases, including MEDLINE, EMBASE, Web of Science, CINAHL, PsychINFO, the Cochrane Library, including the CENTRAL register of Controlled Trials and also the WHO library and ICTRP (International Clinical Trials Registry Platform), which includes the Clinicaltrials.gov repository. We will also search Wanfang Data and the China Knowledge Resource Integrated Database. Included studies must have compared exposure to iodised salt, iodine supplements or iodised oil, to placebo, non-iodised salt or no intervention. Primary outcomes will be continuous and categorical markers of prenatal and postnatal somatic growth. Secondary outcomes will cover further measures of growth, including growth rates and indirect markers of growth such as insulin-like growth factor-1 (IGF-1).
The systematic review will be published in a peer-reviewed journal, and will be sent directly to the WHO, United Nations Children's Fund, International Council for the Control of Iodine Deficiency Disorders and other stakeholders. The results generated from this systematic review will provide evidence to support future programme recommendations regarding iodine fortification or supplementation and child growth.
PROSPERO CRD42014012940.
碘是一种必需的微量营养素，也是甲状腺激素的组成部分。充足的碘摄入对正常生长发育至关重要。如果碘需求未得到满足，生长可能会受到损害。食盐加碘和碘补充剂可以预防碘缺乏症和生长发育迟缓。尚无系统评价整理过将碘与生长联系起来的证据。随着世界卫生组织《2025年全球营养目标》对发育迟缓问题的日益重视，我们提议进行一项系统评价以解决这一问题。
我们将进行一项系统评价，如有必要，还将进行荟萃分析，评估碘盐或碘补充剂对18岁之前的产前和产后身体生长的影响。我们将检索多个数据库，包括MEDLINE、EMBASE、科学网、护理学与健康领域数据库、心理学文摘数据库、考克兰图书馆（包括对照试验中央注册库）以及世界卫生组织图书馆和国际临床试验注册平台（其中包括Clinicaltrials.gov数据库）。我们还将检索万方数据和中国知网。纳入的研究必须将碘盐、碘补充剂或碘油与安慰剂、非碘盐或无干预措施进行比较。主要结局将是产前和产后身体生长的连续和分类指标。次要结局将涵盖生长的进一步指标，包括生长速率以及生长的间接指标，如胰岛素样生长因子-1（IGF-1）。
该系统评价将发表在同行评审期刊上，并将直接发送给世界卫生组织、联合国儿童基金会、国际碘缺乏病控制理事会及其他利益相关方。该系统评价产生的结果将为支持未来有关碘强化或补充以及儿童生长的项目建议提供证据。
PROSPERO CRD42014012940。
