Zheng Mingbin, Zhao Pengfei, Luo Zhenyu, Gong Ping, Zheng Cuifang, Zhang Pengfei, Yue Caixia, Gao Duyang, Ma Yifan, Cai Lintao
Department of Chemistry, Guangdong Medical College , Dongguan 523808, People's Republic of China.
ACS Appl Mater Interfaces. 2014 May 14;6(9):6709-16. doi: 10.1021/am5004393. Epub 2014 Apr 15.
Folic acid (FA)-targeted indocyanine green (ICG)-loaded nanoparticles (NPs) (FA-INPs) were developed to a near-infrared (NIR) fluorescence theranostic nanoprobe for targeted imaging and photothermal therapy of cancer. The FA-INPs with good monodispersity exhibited excellent size and fluorescence stability, preferable temperature response under laser irradiation, and specific molecular targeting to MCF-7 cells with FA receptor overexpression, compared to free ICG. The FA-INPs enabled NIR fluorescence imaging to in situ monitor the tumor accumulation of the ICG. The cell survival rate assays in vitro and photothermal therapy treatments in vivo indicated that FA-INPs could efficiently targeted and suppressed MCF-7 cells and xenograft tumors. Hence, the FA-INPs are notable theranostic NPs for imaging-guided cancer therapy in clinical application.
叶酸（FA）靶向负载吲哚菁绿（ICG）的纳米颗粒（NPs）（FA-INPs）被开发为一种用于癌症靶向成像和光热治疗的近红外（NIR）荧光诊疗纳米探针。与游离ICG相比，具有良好单分散性的FA-INPs表现出优异的尺寸和荧光稳定性、激光照射下较好的温度响应以及对过表达FA受体的MCF-7细胞的特异性分子靶向性。FA-INPs能够进行近红外荧光成像以原位监测ICG在肿瘤中的蓄积。体外细胞存活率测定和体内光热治疗表明，FA-INPs能够有效靶向并抑制MCF-7细胞和异种移植肿瘤。因此，FA-INPs是临床应用中用于成像引导癌症治疗的显著诊疗纳米颗粒。
