用于肿瘤中吲哚菁绿脂质体聚集成像的基于压电环形阵列换能器的双波长光声计算机断层扫描
Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors.
作者信息
Sun Xin, Shan Han, Lin Qibo, Chen Ziyan, Liu Dongxu, Liu Zhankai, Peng Kuan, Chen Zeyu
机构信息
State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
ULSO (Shanghai) Tech Co., Ltd., Shanghai 201821, China.
出版信息
Micromachines (Basel). 2022 Jun 15;13(6):946. doi: 10.3390/mi13060946.
Recently, indocyanine green (ICG), as an FDA-approved dye, has been widely used for phototherapy. It is essential to obtain information on the migration and aggregation of ICG in deep tissues. However, existing fluorescence imaging platforms are not able to obtain the structural information of the tissues. Here, we prepared ICG liposomes (ICG-Lips) and built a dual-wavelength photoacoustic computed tomography (PACT) system with piezoelectric ring-array transducer to image the aggregation of ICG-Lips in tumors to guide phototherapy. Visible 780 nm light excited the photoacoustic (PA) effects of the ICG-Lips and near-infrared 1064 nm light provided the imaging of the surrounding tissues. The aggregation of ICG-Lips within the tumor and the surrounding tissues was visualized by PACT in real time. This work indicates that PACT with piezoelectric ring-array transducer has great potential in the real-time monitoring of in vivo drug distribution.
最近，吲哚菁绿（ICG）作为一种经美国食品药品监督管理局（FDA）批准的染料，已被广泛用于光疗。获取ICG在深部组织中的迁移和聚集信息至关重要。然而，现有的荧光成像平台无法获取组织的结构信息。在此，我们制备了ICG脂质体（ICG-Lips），并构建了一种带有压电环形阵列换能器的双波长光声计算机断层扫描（PACT）系统，以成像ICG-Lips在肿瘤中的聚集情况，从而指导光疗。可见的780 nm光激发ICG-Lips的光声（PA）效应，而近红外1064 nm光提供周围组织的成像。通过PACT可实时观察到肿瘤内部及周围组织中ICG-Lips的聚集情况。这项工作表明，带有压电环形阵列换能器的PACT在体内药物分布的实时监测方面具有巨大潜力。
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