Bérard Anick, Sheehy Odile
Faculté de Pharmacie, Université de Montréal, Montréal, Québec, Canada - Centre de Recherche, CHU Sainte-Justine, Montréal, Québec, Canada.
Centre de Recherche, CHU Sainte-Justine, Montréal, Québec, Canada.
Therapie. 2014 Jan-Feb;69(1):71-81. doi: 10.2515/therapie/2014011. Epub 2014 Apr 4.
Many women are exposed to medications during pregnancy. The Quebec Pregnancy Cohort (QPC) is a prospective population-based cohort which includes all data on pregnancies and children between January 1997 and December 2008.
We linked four administrative databases in Quebec, Canada: RAMQ (medical and pharmaceutical), MED-ECHO (hospitalizations), ISQ (births/deaths), and MELS (Ministry of Education). Pregnancies included were covered by the Quebec prescription drug insurance plan (36% of women aged 15-45 years) from 12 months prior until the end of pregnancy.
We analyzed 97,680 pregnancies. Prevalence of medication use was 74% pre-pregnancy, 56% during pregnancy, and 80% post-pregnancy. Most frequently used medications during pregnancy were antibiotics (47%), antiemetic drugs (23%), and non-steroïdal anti-inflammatory drugs (NSAIDs) [17%]. Medication users were more likely to have spontaneous abortions, preterm births, children with congenital malformations and postpartum depression than non-users (p<0.01).
Medications are commonly used during pregnancy. The QPC is a powerful tool for perinatal pharmacoepidemiological research.
许多女性在孕期会接触到药物。魁北克孕期队列研究（QPC）是一项基于人群的前瞻性队列研究，涵盖了1997年1月至2008年12月期间所有关于妊娠和儿童的数据。
我们将加拿大魁北克的四个行政数据库进行了关联：RAMQ（医疗和药品）、MED-ECHO（住院治疗）、ISQ（出生/死亡）和MELS（教育部）。纳入的妊娠是指魁北克处方药保险计划覆盖的妊娠（年龄在15 - 45岁的女性中的36%），从妊娠前12个月直至妊娠结束。
我们分析了97,680例妊娠。妊娠前用药患病率为74%，孕期为56%，产后为80%。孕期最常用的药物是抗生素（47%）、止吐药（23%）和非甾体抗炎药（NSAIDs）[17%]。与未用药者相比，用药者发生自然流产、早产、先天性畸形儿童和产后抑郁的可能性更大（p<0.01）。
孕期常用药物。QPC是围产期药物流行病学研究的有力工具。
