Simon Stéphane R J, Tomson Phillip L, Berdal Ariane
Department of Oral Biology, School of Dentistry, University of Paris Diderot, Paris, France; Hôpital de la Pitié Saléptrière, Paris, France; UMRS INSERM 1138 TEAM 5, Paris, France; Oral Biology, School of Dentistry, University of Birmingham, United Kingdom.
Oral Biology, School of Dentistry, University of Birmingham, United Kingdom.
J Endod. 2014 Apr;40(4 Suppl):S70-5. doi: 10.1016/j.joen.2014.01.024.
Recent advances in biotechnology and translational research have made it possible to provide treatment modalities that protect the vital pulp, allow manipulation of reactionary and reparative dentinogenesis, and, more recently, permit revascularization of an infected root canal space. These approaches are referred to as regenerative procedures. The method currently used to determine the origin of the tissue secreted during the repair/regeneration process is largely based on the identification of cellular markers (usually proteins) left by cells that were responsible for this tissue production. The presence of these proteins in conjunction with other indicators of cellular behavior (especially biomineralization) and analysis of the structure of the newly generated tissue allow conclusions to be made of how it was formed. Thus far, it has not been possible to truly establish the biological mechanism controlling tertiary dentinogenesis. This article considers current therapeutic techniques to treat the dentin-pulp complex and contextualize them in terms of reparative and regenerative processes. Although it may be considered a semantic argument rather than a biological one, the definitions of regeneration and repair are explored to clarify our position in this era of regenerative endodontics.
生物技术和转化研究的最新进展使得提供保护牙髓、控制反应性和修复性牙本质形成，以及最近实现感染根管空间再血管化的治疗方式成为可能。这些方法被称为再生程序。目前用于确定修复/再生过程中分泌组织来源的方法主要基于对负责该组织产生的细胞留下的细胞标记物（通常是蛋白质）的鉴定。这些蛋白质的存在与细胞行为的其他指标（特别是生物矿化）以及对新生成组织结构的分析，使得我们能够推断其形成方式。到目前为止，尚未能够真正建立控制第三期牙本质形成的生物学机制。本文探讨了当前治疗牙本质-牙髓复合体的技术，并将其置于修复和再生过程的背景下进行考量。尽管这可能被视为一个语义上的争论而非生物学上的争论，但本文仍对再生和修复的定义进行了探讨，以阐明我们在这个再生牙髓病学时代的立场。
