Bennett T, Gardiner S M
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, England.
J Cardiovasc Pharmacol. 1988;12 Suppl 8:S1-10.
Most putative studies on the physiology of the aging cardiovascular system in humans have been cross-sectional. The results are therefore bedeviled by selective mortality and probably influenced by subclinical disease processes. Even accepting these problems, critical reading of the published literature shows that there is very little substantive evidence for the "well-known" age-related changes in cardiovascular physiology such as baroreflex impairment, sympathetic hyperactivation, adrenoceptor dysfunction, or neurohumoral abnormalities.
大多数关于人类心血管系统衰老生理学的假设性研究都是横断面研究。因此，结果受到选择性死亡率的困扰，并且可能受到亚临床疾病过程的影响。即使承认这些问题，仔细阅读已发表的文献也会发现，几乎没有实质性证据支持心血管生理学中“众所周知”的与年龄相关的变化，如压力反射受损、交感神经亢进、肾上腺素能受体功能障碍或神经体液异常。
