Breckenridge A
University of Liverpool, England.
J Cardiovasc Pharmacol. 1988;12 Suppl 8:S100-4.
In spite of the fact that plasma renin activity declines with age and drugs whose action is mediated via the renin-angiotensin system might be expected to be less effective with increasing age, the limited available data suggest that both captopril and enalapril lower blood pressure in the elderly. The quantity and the quality of data to compare hypotensive effects in the young and elderly leave much to be desired. It might be predicted that adverse effects such as hypotension and exacerbation of preexisting renal failure could pose problems for the use of these drugs in the elderly, but documentation of this is also sparse. Clearly, this area of risk versus benefit of angiotensin converting enzyme (ACE) inhibitors in the elderly requires further study.
尽管血浆肾素活性会随着年龄增长而下降，且作用通过肾素 - 血管紧张素系统介导的药物可能会随着年龄增长而疗效降低，但现有有限数据表明，卡托普利和依那普利均可降低老年人的血压。用于比较年轻人和老年人降压效果的数据在数量和质量上都有很大欠缺。可以预测，诸如低血压和原有肾衰竭加重等不良反应可能会给这些药物在老年人中的使用带来问题，但这方面的文献记载也很少。显然，老年患者使用血管紧张素转换酶（ACE）抑制剂的风险与获益这一领域需要进一步研究。
