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[转换酶抑制剂在老年高血压患者治疗中的应用]

[Converting-enzyme inhibitors in the treatment of elderly hypertension patients].

作者信息

Amery A, Buyamba-Kabangu J R, Fagard R, Lijnen P, Staessen J, van Hoof R

机构信息

Hypertension Unit, U.Z. Gasthuisberg Leuven, Belgien.

出版信息

Wien Med Wochenschr. 1990 Jan 31;140(1-2):30-4.

PMID:2408248
Abstract

According to this review of available data on converting enzyme inhibitors in elderly hypertensives, the drugs' hypotensive action has been clearly established and seems to be similar in degree to that of diuretics. Adverse reactions during converting enzyme inhibitor treatment in the elderly may be slightly more frequent than in younger patients, but whether this is related to the drugs themselves or to the general characteristics of elderly hypertensives has not been established. Likewise, whether or not the hypotensive action of converting enzyme inhibitors is age-related is as yet unknown. Finally, studies on the impact of converting enzyme inhibitors on morbidity, mortality and general well being in elderly patients have not been carried out or published. Thus, while the drugs appear to have usefulness in the older hypertensive, their benefits and precise use in this age group are not as yet definitive.

摘要

根据这篇对老年高血压患者使用转换酶抑制剂的现有数据的综述,这类药物的降压作用已得到明确证实,其程度似乎与利尿剂相似。老年患者在接受转换酶抑制剂治疗期间的不良反应可能比年轻患者略多,但这是否与药物本身有关,还是与老年高血压患者的一般特征有关,尚未明确。同样,转换酶抑制剂的降压作用是否与年龄有关目前也尚不清楚。最后,关于转换酶抑制剂对老年患者发病率、死亡率和总体健康状况影响的研究尚未开展或发表。因此,虽然这类药物似乎对老年高血压患者有用,但它们在该年龄组中的益处和确切用法尚未确定。

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