1] Division of Biochemistry, Cancer Genomics Center, Netherlands Cancer Institute, Amsterdam, The Netherlands. [2].
Division of Biochemistry, Cancer Genomics Center, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Nat Struct Mol Biol. 2014 Apr;21(4):308-16. doi: 10.1038/nsmb.2792.
Ubiquitin and ubiquitin-like modifications are central to virtually all cellular signaling pathways. They occur primarily on lysine residues of target proteins and stimulate a large number of downstream signals. The diversity of these signals depends on the type, location and dynamics of the modification, but the role of the exact site of modification and the selectivity for specific lysines are poorly understood. Here we review the current literature on lysine specificity in these modifications, and we highlight the known signaling mechanisms and the open questions that pose future challenges to ubiquitin research.
泛素和类泛素修饰是几乎所有细胞信号通路的核心。它们主要发生在靶蛋白的赖氨酸残基上，并刺激大量下游信号。这些信号的多样性取决于修饰的类型、位置和动态，但修饰的确切位点和特定赖氨酸的选择性作用尚不清楚。在这里，我们回顾了目前关于这些修饰中赖氨酸特异性的文献，并强调了已知的信号机制和悬而未决的问题，这些问题对泛素研究构成了未来的挑战。
