Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Nutrients. 2014 Apr 2;6(4):1364-73. doi: 10.3390/nu6041364.
Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation. In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms.
几项研究表明，在肥胖发生前补充 l-亮氨酸可减少肥胖。我们研究了在开始补充 l-亮氨酸之前暴露于高脂肪饮食（HFD） 10 周的大鼠。补充 l-亮氨酸的大鼠在摄入 HFD 时脂肪量增加。因此，l-亮氨酸产生了有利于脂肪积累的下丘脑基因表达模式。总之，l-亮氨酸的补充可能通过中枢机制使先前暴露于 HFD 的大鼠的肥胖恶化。
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