基质辅助激光解吸电离飞行时间质谱作为不断发展的癌症诊断工具：综述
MALDI-TOF MS as evolving cancer diagnostic tool: a review.
作者信息
Rodrigo Miguel Angel Merlos, Zitka Ondrej, Krizkova Sona, Moulick Amitava, Adam Vojtech, Kizek Rene
机构信息
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czech Republic.
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czech Republic.
出版信息
J Pharm Biomed Anal. 2014 Jul;95:245-55. doi: 10.1016/j.jpba.2014.03.007. Epub 2014 Mar 15.
Recent developments in mass spectrometry have introduced clinical proteomics to the forefront of diseases diagnosis, offering reliable, robust and efficient analytical method for biomarker discovery and monitoring. MALDI-TOF is a powerful tool for surveying proteins and peptides comprising the realm for clinical analysis. MALDI-TOF has the potential to revolutionize cancer diagnostics by facilitating biomarker discovery, enabling tissue imaging and quantifying biomarker levels. Healthy (control) and cancerous tissues can be analyzed on the basis of mass spectrometry (MALDI-TOF) imaging to identify cancer-specific changes that may prove to be clinically useful. We review MALDI-TOF profiling techniques as tools for detection of cancer biomarkers in various cancers. We mainly discuss recent advances including period from 2011 to 2013.
质谱技术的最新进展已将临床蛋白质组学推向疾病诊断的前沿，为生物标志物的发现和监测提供了可靠、强大且高效的分析方法。基质辅助激光解吸电离飞行时间质谱（MALDI-TOF）是一种用于检测构成临床分析领域的蛋白质和肽段的强大工具。MALDI-TOF有潜力通过促进生物标志物的发现、实现组织成像以及量化生物标志物水平来彻底改变癌症诊断。健康（对照）组织和癌组织可基于质谱（MALDI-TOF）成像进行分析，以识别可能具有临床应用价值的癌症特异性变化。我们综述了MALDI-TOF分析技术作为检测各种癌症中癌症生物标志物的工具。我们主要讨论了2011年至2013年期间的最新进展。
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