芬兰唾液腺癌的家族易感性。
Familial predisposition for salivary gland cancer in Finland.
作者信息
Aro Katri, Klockars Tuomas, Leivo Ilmo, Mäkitie Antti
机构信息
Deparment of Otolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Department of Pathology, University of Turku, Turku, Finland.
出版信息
Clin Med Insights Ear Nose Throat. 2014 Mar 24;7:7-11. doi: 10.4137/CMENT.S13770. eCollection 2014.
BACKGROUND
Salivary gland cancer (SGC) accounts for 3-5% of head and neck malignancies, and register-based studies estimate the familial proportion to be 0.15%.
OBJECTIVE
We studied familial predisposition for SGC in the genetically distinct Finnish population.
PATIENTS AND METHODS
We sent a patient questionnaire to 161 Finnish SGC patients, 86 of whom responded.
RESULTS
A total of 76% of the patients reported having one or more relatives with cancer, 30% two or more, and 9% three or more but only one patient reported having a relative with SGC. Tracing the birthplaces of the SGC patients' grandparents showed no regional clustering suggestive of a founder effect.
CONCLUSIONS
Lack of familial SGC patients and the absence of a founder effect strongly suggest that familial predisposition for SGC is insignificant in the Finnish population. Various histological subtypes and the rarity of these neoplasms make it impossible to draw conclusions about site-specific association between SGC and other malignancies.
背景
涎腺癌（SGC）占头颈部恶性肿瘤的3% - 5%，基于登记的研究估计其家族性比例为0.15%。
目的
我们在基因独特的芬兰人群中研究了涎腺癌的家族易感性。
患者与方法
我们向161名芬兰涎腺癌患者发送了患者问卷，其中86人进行了回复。
结果
共有76%的患者报告有一位或多位患癌亲属，30%报告有两位或更多，9%报告有三位或更多，但只有一名患者报告有患涎腺癌的亲属。追溯涎腺癌患者祖父母的出生地未发现提示奠基者效应的区域聚集。
结论
缺乏家族性涎腺癌患者以及不存在奠基者效应强烈表明，在芬兰人群中涎腺癌的家族易感性不显著。这些肿瘤的各种组织学亚型及其罕见性使得无法得出涎腺癌与其他恶性肿瘤之间部位特异性关联的结论。
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