Luukkaa Heikki, Klemi Pekka, Leivo Ilmo, Koivunen Petri, Laranne Jussi, Mäkitie Antti, Virtaniemi Jukka, Hinkka Susanna, Grénman Reidar
Department of Otorhinolaryngology--Head and Neck Surgery, University of Turku, Turku, Finland.
Acta Otolaryngol. 2005 Feb;125(2):207-14. doi: 10.1080/00016480510003174.
In this material consisting of various salivary gland carcinomas, stage I, male gender and age were the most powerful predictors of patient outcome.
To retrieve the records of all salivary gland cancer (SGC) patients diagnosed in Finland between 1991 and 1996 and to evaluate the incidence, histological type and location of SGC, the treatment given and the outcome.
The records for all SGCs (n =286) diagnosed in Finland between 1991 and 1996 and reported to the Finnish Cancer Registry were retrieved. The histological re-evaluation and retrospective study involved 237 SGC patients.
The study population consisted of 125 males and 112 females. The mean age was 59 years (males 61 years, females 58 years). Follow-up was at least 5 years. The commonest tumor location was the parotid gland (n = 152; 64%), followed by the minor salivary glands (n =46; 19%), the submandibular gland (n =38; 16%) and the sublingual gland (n = 1; 0.4%). The most frequent histological types of SGC were adenoid cystic carcinoma (n =65; 27%), mucoepidermoid carcinoma (n =45; 19%) and acinic cell carcinoma (n =41; 17%). Surgery, either alone or in combination with other treatment modalities, was used in 209 cases (88%). Radiotherapy was given to 136 patients (57%), 13 of whom (5%) did not undergo surgery. The 5-year overall survival rate was 56.5%, and for stages I-IV it was 78%, 25%, 21% and 23%, respectively (p <0.001; log-rank test). Of the commonest tumor types, the best 5-year relative survival rate was for patients with acinic cell carcinoma (96%), followed by those with mucoepidermoid (79%) and adenoid cystic carcinoma (74%).
在这种包含各种涎腺癌的材料中，I期、男性性别和年龄是患者预后最有力的预测因素。
检索1991年至1996年期间在芬兰诊断的所有涎腺癌（SGC）患者的记录，并评估SGC的发病率、组织学类型和位置、所给予的治疗及预后。
检索了1991年至1996年期间在芬兰诊断并报告给芬兰癌症登记处的所有SGC病例（n = 286）。组织学重新评估和回顾性研究涉及237例SGC患者。
研究人群包括125名男性和112名女性。平均年龄为59岁（男性61岁，女性58岁）。随访至少5年。最常见的肿瘤部位是腮腺（n = 152；64%），其次是小涎腺（n = 46；19%）、下颌下腺（n = 38；16%）和舌下腺（n = 1；0.4%）。SGC最常见的组织学类型是腺样囊性癌（n = 65；27%）、黏液表皮样癌（n = 45；19%）和腺泡细胞癌（n = 41；17%）。209例（88%）患者采用了单独手术或与其他治疗方式联合的治疗方法。136例患者（57%）接受了放疗，其中13例（5%）未接受手术。5年总生存率为56.5%，I - IV期的生存率分别为78%、25%、21%和23%（p < 0.001；对数秩检验）。在最常见的肿瘤类型中，5年相对生存率最佳的是腺泡细胞癌患者（96%），其次是黏液表皮样癌患者（79%）和腺样囊性癌患者（74%）。
