Temple D M, McCluskey M
Department of Pharmacology, University of Sydney, Australia.
Prostaglandins. 1988 Apr;35(4):549-54. doi: 10.1016/0090-6980(88)90030-5.
Some H1-antihistamines possess anti-allergic properties, and inhibit the immunological release of mediators including histamine and sulfiopeptide-leukotrienes (slow reacting substance of anaphylaxis) from lung. The effects of the antihistiamine loratadine, SCH29851, on the release of leukotrienes and histamine from human lung fragments were measured, using the calcium ionophore A23187 and an extract of antigen from Dermatophagoides pteronyssinus, house dust mite, (with passively sensitized lung) as releasing agents. Loratadine (1-20 microM) inhibited the release of leukotrienes in a concentration-dependent manner when release was induced by calcium ionophore from lung specimens from 8 subjects, and also when release was induced by antigen from lung specimens from 7 subjects. Histamine release was unaffected by these concentrations of loratadine in both types of experiment.
一些H1抗组胺药具有抗过敏特性，可抑制包括组胺和硫肽白三烯（过敏反应迟缓物质）在内的介质从肺中免疫释放。使用钙离子载体A23187和来自屋尘螨（被动致敏肺）的抗原提取物作为释放剂，测定了抗组胺药氯雷他定（SCH29851）对人肺组织中白三烯和组胺释放的影响。当用钙离子载体诱导8名受试者肺标本释放时，以及用抗原诱导7名受试者肺标本释放时，氯雷他定（1 - 20微摩尔）均以浓度依赖性方式抑制白三烯的释放。在这两种实验类型中，这些浓度的氯雷他定均未影响组胺释放。
